人工颈椎间盘置换术能否取代ACDF

目前颈椎病的治疗主要采用切除病变椎间盘和椎体间融合的手术方法,而人工颈椎间盘置换术的临床应用预示着脊柱外科治疗学新纪元的开始。简要介绍了Byran人工颈椎间盘置换术,对其临床效果进行了随访和分析,总结了人工颈椎间盘置换术的治疗优势和临床应用中的问题。客观评价了人工颈椎间盘技术,为临床决策提供了实践依据。     

纤维乳管镜临床应用中的问题与争议

纤维乳管镜主要应用于乳头溢液的诊断,提高了诊断的准确率,减小了手术切除范围,并修改了部分乳腺疾病的手术指征.但由于乳腺导管系统解剖的复杂性以及乳管镜本身的限制,乳管镜在乳腺导管内病变的切除、导管炎症治疗、乳腺癌筛查、保乳手术中辅助判定切缘等临床应用方面,尚存在诸多的问题与争议.     

临床外伤性视神经病变过度医疗的探讨

外伤性视神经病变是一类严重损害视功能的疾病,临床治疗上普遍存在着过度治疗的问题.原因是多样的,治疗标准不统一是主要原因.依据循证医学的成果,对临床外伤性视神经病变现阶段存在的过度医疗进行分析探讨,并提出了医者针对外伤性视神经病变过度医疗应采取的措施,获得最优化的诊疗方案.     

人工腰椎间盘置换预示了腰椎融合的终结？

腰椎间盘退变性疾患的治疗方法主要是病变椎间盘的单纯切除和腰椎融合。而人工腰椎间盘置换的出现预示了脊柱外科一个新的时代的到来。简要介绍SB charité人工腰椎间盘置换技术,并分析了其早期的临床效果及可能出现的一些并发症,总结了目前人工腰椎间盘的应用所遇到的一些问题。客观的评价人工腰椎间置换技术,为临床实践和进一步研究提供依据。     

皮肤缺损与皮瓣修复治疗的分析与思考

皮瓣移植是整形外科治疗皮肤缺损的重要方法.为皮瓣修复治疗更好的临床效果,需要在正确分析病情的基础上,兼顾医疗技术,关注预后,把握皮瓣修复治疗的指征;同时注重疾病的系统和综合治疗,并不断进行理论创新、技术创新,以促进皮瓣外科的发展.唯物辩证法的矛盾论、系统论和发展现对临床治疗具有普遍的指导意义.     

腹主动脉瘤的外科治疗决策

腹主动脉瘤破裂是最常见、最凶险的疾病之一.提高对其治疗的临床决策水平至关重要.比较传统开腹修复治疗和血管腔内修复治疗的优缺点.以最佳证据为指导,选出最佳方案应用于临床实践.以人为本,做出科学决策,从而降低医疗费用及提高疗效及患者生活质量.     

视网膜手术的发展与思考

视网膜脱离是严重的致盲性眼病之一.视网膜玻璃体疾病的手术治疗是从20世纪开始,首先是Gonin面开辟的视网膜脱离的手术治疗,使得这一疾病从不治变为可治.20世纪70年代以后,玻璃体手术的出现,各种玻璃体替代物更新与临床应用,使视网膜脱离的手术进一步完善与提高.尤其是80年代以后,各种膨胀气体、硅油、全氟化碳液体的应用、眼内光凝、视网膜切开与切除技术的应用,对增生性玻璃体视网膜病变(PVR)的认识和研究不断地深入,尤其是前部PVR的研究等,使玻璃体手术适应症逐步拓宽,手术技术日新月异,视网膜玻璃体手术成功率大大提高.     

远外侧入路治疗颅颈交界区腹侧病变

探讨远外侧入路在颅颈交界区腹侧病变治疗中的应用.14例患者全部采用远外侧入路显微手术治疗.11例肿瘤全切除7例,次全切除2例,大部切除2例;3例动脉瘤均顺利夹闭;行枕颈融合术3例.术后最常见的并发症是后组脑神经损伤症状;获得随访11例,恢复良好.远外侧入路是治疗颅颈交界区腹侧病变的理想入路,但治疗方案应个体化.     

口腔颌面肿瘤切除与修复平衡点的临床决策及思考

口腔颌面肿瘤切除与修复"平衡点"的设立来自于临床实践,肿瘤种类不同、患者个体不同其平衡点也不同,是个体化的平衡点。肿瘤切除与缺损修复是一个矛盾的两个方面,是对立统一的关系,平衡点是肿瘤切除与修复辩证统一的具体体现。切除与修复平衡点决策遵循的基本方法是循证医学,标准流程是由临床医生,按照患者的具体情况和要求,获取目前国际上最新的研究证据,结合临床经验确定肿瘤手术切除与修复的平衡点,并在医疗活动中实现。     

人工椎间盘置换术中的循证医学证据

循证医学(evidence-based medicine,EBM)作为一门新兴的交叉学科越来越广泛地被用来进行临床评估和决策.人工椎间盘置换技术的发展为椎间盘退行性病变的治疗提供了符合现代医学模式的新方法.循证医学在人工椎间盘置换研究中的应用不仅有助于为其提供可信、有力的临床证据,而且有丰富的哲学内涵.     

Lumbale Radikulopathie

Back pain is a common pain syndrome in the general population. The most common cause is lumbar disc disease and only rarely bony degenerative changes of the spine. Other causes of lumbar radiculopathy include local lesions. Inflammatory changes or meningeal carcinomatosis may also lead to lumbar nerve root damage. With pronounced clinical symptoms, motor deficits of the associated muscles can occur, including weakening of muscle reflexes. In addition to thorough education of the patient about the origin, likely duration, and treatment of the disease, a combination of physical therapy and pharmacotherapy is the basis for successful treatment of lumbar radiculopathy. In cases of severe paralysis, bladder and rectal paralysis, and corresponding compression of nerves, urgent spinal surgery is inevitable.     

经验医学与腰椎间盘突出症的认知史

众所周知,腰椎间盘突出症是一种脊柱退变性疾病。本病的发现历史只有70多年,但它的存在历史却至少有几千年了。本文从有记载开始的古代文明回顾了腰椎间盘突出症的存在和发现过程,特别强调经验医学在疾病认知过程中的重要作用。本文还重点提出当代保守治疗和手术治疗的进展和原则变化情况。另外,根据最近的临床研究,本文认为,脊柱力学平衡在保守治疗过程中应该引起足够的临床重视。     

椎体成形术和球囊扩张椎体后凸成形术治疗骨质疏松性椎体压缩骨折的对比研究

为对比分析椎体成形术（PVP）与球囊扩张椎体后凸成形术（PKP）治疗骨质疏松性椎体压缩骨折的临床疗效。共治疗患者45例。PVP25例,PKP20例。所有患者术后疼痛均明显减轻或消失,PVP组与PKP组两组相比,术后的伤椎及相邻椎间隙高度、脊柱后凸Cobb角及ODI评分差异有统计学意义（P〈0．05）。PKP能够更好的恢复骨折椎体的高度,矫正脊柱后凸畸形,改善脊柱功能,明显减少骨水泥渗漏,临床效果较PVP更为满意。     

Plasticity: implications for opioid and other pharmacological interventions in specific pain states

The spinal mechanisms of action of opioids under normal conditions are reasonably well understood. The spinal effects of opioids can be enhanced or reduced depending on pathology and activity in other segmental and nonsegmental pathways. This plasticity will be considered in relation to the control of different pain states using opioids. The complex and contradictory findings on the supraspinal actions of opioids are explicable in terms of heterogeneous descending pathways to different spinal targets using multiple transmitters and receptors--therefore opioids can both increase and decrease activity in descending pathways. These pathways could exhibit considerable plasticity. There is increasing evidence that delta opioid receptor agonists have the potential to replace morphine as major analgesics with reduced side-effect profiles. The concept of preemptive analgesia, based on preventing the induction of some of the negative plastic influences on opioid controls and the detrimental effects of pain, is sound, but experimental verification in the clinical setting is difficult. For example, a delayed compensatory upregulation of inhibitory systems, particularly in inflammation, may counter persistent painful inputs. Combination therapy with opioids may be beneficial in many pain states where either negative influences are blocked or inhibitory controls are enhanced. Finally, developmental aspects of these systems are discussed in connection with the treatment of pain in young children, where inhibitory systems in the spinal cord are immature.     

骨质疏松症对腰椎形态及其大体活动范围的影响

了解不同程度骨质疏松患者椎骨、椎间盘形态及腰椎矢状面大体活动度。选取34位在我院查体的老年人,并按骨密度值分组(9正常,11骨量缺少,14骨质疏松症),拍摄腰椎侧位片及磁共振图像,并测量活动度。骨质疏松组与其他两组相比,腰椎椎体前部高度增加,骨质疏松与椎间盘中部膨胀和相应椎体的塌陷有关,而与椎间盘性质无关,其腰椎大体活动范围无明显变化。骨质疏松不仅影响骨矿含量,也影响骨周围软组织,且与椎体终板变化继发椎间盘膨胀相关。     

不同植骨方式应用于退行性腰椎滑脱症后路手术的疗效分析

为了比较后路椎阎植骨融合（posterior lumber interbody fusion,PLIF）、后外侧植骨融合（posterolateral lumbar fusion,PLF）及二者联合运用（PLIF＋PLF）在退行性腰椎滑脱症后路手术中的疗效,对59例退行性腰椎滑脱症患者根据手术中植骨方式分为三组,回顾三组患者的临床资料,比较三种植骨融合方式手术时间、术中出血量、椎间隙高度、滑脱角、植骨融合率以及JOA评分改善率。结果显示：B组（PLF）的植骨融合率低于A组（PLIF）及C组（PLIF＋PLF）。在椎间隙高度维持、滑脱角丢失等方面A组优于B组（P〈0．05）,并且与C组无差异（P〉0．05）。在手术时间及术中出血量方面A组优于C组（P〈0．05）,并且与B组无差异（P〉0．05）。JOA评分改善率比较,三组间无显著性差异（P〉O0．05）。因此,得出结论：PLIF和PLF均是退行性腰椎滑脱症后路手术中的有效融合方式;PLIF及PLIF＋PLF的融合率优于PLF;综合分析PLIF应用于退行性腰椎滑脱症后路手术中优于PLF及PLIF＋PLF。     

Surgery of therapy-resistant pain due to peripheral nerve injury]

1. The forms of peripherally triggered or localized pains are differentiated: Local pain of a neuromatous character, propagated pain, sympathalgia, phantom pain, causalgia, and combined forms. 2. Surgical operations are performed locally, to the spinal cord, brain, and sympathicus, as well as by neurostimulation on all levels. 3. The areas of indication differ according to the localization of pain and its probable cause. 4. Serving the prevention of pain after peripheral nerve injuries are the particular topical treatment of a fresh injury, psychic guidance, specific aftercare and physiotherapy, elimination of pension payment problems, and optimum reintegration into normal working life]     

Discrimination of amount of spinal flexion for movements made with and without vision after lumbar disc replacement

Discrimination of differences between small lumbar flexion movements made when standing may differ depending on whether vision is available. Dependence on general vision during trunk movements may be increased following surgery, in which an intervertebral disc is replaced with a prosthetic disc. This study investigated whether the availability of vision changed discrimination of small differences in lumbar forward flexion movement when standing for patients with lumbar disc replacement and healthy peers. 20 volunteers without a history of back pain and 20 with disc replacement undertook a 100-trial sequence of forward flexion movements to a set of physical stops, making an absolute judgement as to the position after each movement. General (nontarget) vision during the movement was available or removed randomly trial by trial. Availability of vision did not affect discrimination of flexion movements of the lumbar spine either in normal healthy individuals or those with disc replacement.     

Clinician's comment on the management of pain in arthritis.

The arthritic diseases are major sources of pain or disability, although they differ in etiology and treatment approach. For diseases such as RA, inflammation is the predominant mechanism that leads to systemic complaints such as pain as well as local destruction of cartilage and bone. In contrast, OA is primarily a degenerative process and, although inflammation may occur, it differs in quality and extent from that in the systemic inflammatory arthritidies. For both conditions, psychosocial interventions have significant positive benefits, but their application involves careful consideration of a variety of factors. These factors include the following: diagnosis, disease activity, damage, disease stage, patient age and demographics, presence of comorbidities, and availability of alternative or adjunctive approaches.