口腔颌面部鳞状细胞癌的综合序列治疗

口腔颌面部鳞状细胞癌(鳞癌)在头颈部肿瘤的发病和治疗中占有重要地位,综合序列治疗的概念和理论逐渐成为口腔颌面部鳞癌治疗的指导原则.本文对口腔颌面部鳞癌综合序列治疗所包含的手术治疗、放射治疗、化学治疗及生物治疗从临床治疗策略上进行分析、讨论,以期促进口腔颌面部鳞癌综合序列治疗原则在临床获得更好地应用.     

APC及p63在人口腔鳞状细胞癌发生中的表达及病理意义

为了探讨抑癌基因APC及p63在口腔鳞状细胞癌中的蛋白表达水平和病理意义,实验收集46例人口腔鳞癌石蜡包埋组织,采用elivision染色法检测口腔正常黏膜上皮、上皮异常增生和口腔鳞癌组织中的APC及p63的表达变化,最后将各组份的免疫组化结果与各病例的临床病理学资料使用Kruskal- Wallis检验或Spearman相关性检验,进行统计学处理.结果显示APC蛋白胞浆表达水平与口腔鳞癌的分化呈正相关(P＜0.05),p63蛋白胞核表达水平与口腔鳞癌的分化呈负相关(P＜0.05).APC与其淋巴结有否转移无相关性,而p63与其淋巴结转移有否呈负相关(P＜0.05).因此,APC及p63的表达与口腔鳞癌的发生密切相关,而且与口腔鳞癌的分化程度有关,提示APC和p63可作为口腔鳞癌的发生和预后的检测指标.     

口腔颌面部脉管畸形两种非手术治疗方案比较

在治疗口腔颌面部脉管畸形的众多治疗方法中,激光治疗和瘤腔内药物注射是两种最为常用而且有效的非手术治疗手段。本文通过结合两者各自的优缺点,利用比较治疗学相关原理和方法,从治疗方法、治疗效果、治疗费用等方面对两者进行比较,以便获得一些启发,为临床治疗提供一定的借鉴。     

口腔颌面部脉管畸形两种非手术治疗方案比较

在治疗口腔颌面部脉管畸形的众多治疗方法中,激光治疗和瘤腔内药物注射是两种最为常用而且有效的非手术治疗手段.本文通过结合两者各自的优缺点,利用比较治疗学相关原理和方法,从治疗方法、治疗效果、治疗费用等方面对两者进行比较,以便获得一些启发,为临床治疗提供一定的借鉴.     

正确认识心理因素在颞颌关节紊乱病中的作用

颞颌关节紊乱病(temporomandibular disorder,TMD)是口腔颌面部常见的疾病之一。TMD病因比较复杂,目前认为是多种因素作用的结果,主要为心理因素、牙合因素等。但是目前对于心理因素在TMD的发生、发展、治疗和转归方面,很多学者尚持有异议。运用系统论中的整体性原则、动态性原则、系统涨落理论、综合性原则和最佳化原则等阐明如何才能获得对心理因素在TMD中的作用的全面认识,并指出重视心理因素在TMD中的作用也是顺应医学模式转变,体现人文关怀的需要。     

正确认识心理因素在颞颌关节紊乱病中的作用

颞颌关节紊乱病(temporomndibular disprder,TMD)是口腔颌面部常见的疾病之一.TMD病因比较复杂,目前认为是多种因素作用的结果,主要为心理因素、牙合因素等.但是目前对于心理因素在TMD的发生、发展、治疗和转归方面,很多学者尚持有异议.运用系统论中的整体性原则、动态性原则、系统涨落理论、综合性原则和最佳化原则等阐明如何才能获得对心理因素在TMD中的作用的全面认识,并指出重视心理因素在TMD中的作用也是顺应医学模式转变,体现人文关怀的需要.     

反馈规律在口腔修复学中的作用

反馈作为一种辩证综合思维过程 ,在现代科学研究中日益发挥着重要作用[1] 。本文仅从口腔修复这一分支领域谈点粗浅的认识。1　口腔修复临床诊治过程中的反馈规律及义齿失败的原因分析口腔修复是口腔医学的一门分支学科 ,其主要内容是采用符合生理的方法修复口腔及颌面部各种缺损。在临床就诊的病中 ,绝大多数病人都是因各种原因造成部分或全部牙齿缺失 ,所以义齿修复工作便成为口腔修复临床工作的主要内容。而在实际工作中 ,口腔修复的临床医生如果要想了解义齿修复后达到的效果及存在的问题 ,就必须从病人那里得到反馈信息。这里 ,我们可…     

试论口腔修复学

试论口腔修复学中国医科大学口腔医院（沈阳１１０００１）郑晓辉口腔修复学是研究用符合生理的方法修复口腔与颌面部各种缺损及缺失的一门科学。随着人们对形体与容貌美的追求,美容与牙齿修复的关系越来越显得突出。一、牙齿美与心理健康牙齿是口腔颌面部的重要组成部分...     

唇腭裂患儿常见的心理行为问题及对策

唇腭裂是最常见的口腔颌面部先天性发育畸形。手术修复早已在世界各个国家普遍展开,但患者在形态功能以及心理行为等各方面存在的问题不是单一的学科可以解决的。随着医学模式的转变,以及行为医学和发展心理学等学科的进展,患者在临床治疗工作中的心理和行为问题越来越受到重视。本文将对常见的心理行为问题及其相关对策进行探讨。     

口腔专业适宜技术与诊疗最优化

推行适宜技术和诊疗最优化的原则是避免过度医疗的有效途径。而在口腔专业中必须要体现其特殊性。口腔治疗的总体目标是健康、美观,这一目标有赖于患者的主观评价;患者在治疗中具有自主选择的权利,而医生提供专业上的支持和具体的执行。因此口腔科适宜技术的基本要求是:适合患者的自身条件和需求、符合医学专业诊疗原则的要求以及适合医生的个人技术水平。然而对于我国现阶段而言,适宜技术是一个宽泛且较低的标准,而口腔临床工作中应该以最优化的治疗作为实际追求的目标。     

Sequential combinations of drug and cognitive behavioral therapy for chronic insomnia: an exploratory study

This study explores the efficacy of sequential treatments involving medication and cognitive behavioral treatment (CBT) for primary insomnia. Seventeen participants took part in a multiple baseline design and were assigned to: (a) medication for 5 weeks, followed by combined medication plus CBT for 5 weeks; (b) combined treatment for 5 weeks, followed by CBT alone; or (c) CBT alone. Each treatment sequence produced significant sleep improvements, but at different points in time. For the first sequence, most of the sleep improvement was obtained after the introduction of CBT, while for the other sequence and CBT alone, improvement appeared during the first weeks. These results suggest that sleep improvement seems affected by the way treatments are combined. Also, a sequence beginning with a combined treatment followed by CBT alone seems to produce the best outcome. Additional research should be conducted with larger samples to determine the most effective sequence.     

Situation models and memory: the effects of temporal and causal information on recall sequence

Participants watched an episode of the television show Cheers on video and then reported free recall. Recall sequence followed the sequence of events in the story; if one concept was observed immediately after another, it was recalled immediately after it. We also made a causal network of the show's story and found that recall sequence followed causal links; effects were recalled immediately after their causes. Recall sequence was more likely to follow causal links than temporal sequence, and most likely to follow causal links that were temporally sequential. Results were similar at 10-minute and 1-week delayed recall. This is the most direct and detailed evidence reported on sequential effects in recall. The causal network also predicted probability of recall; concepts with more links and concepts on the main causal chain were most likely to be recalled. This extends the causal network model to more complex materials than previous research.     

Situation models and memory: The effects of temporal and causal information on recall sequence

Participants watched an episode of the television show Cheers on video and then reported free recall. Recall sequence followed the sequence of events in the story; if one concept was observed immediately after another, it was recalled immediately after it. We also made a causal network of the show's story and found that recall sequence followed causal links; effects were recalled immediately after their causes. Recall sequence was more likely to follow causal links than temporal sequence, and most likely to follow causal links that were temporally sequential. Results were similar at 10-minute and 1-week delayed recall. This is the most direct and detailed evidence reported on sequential effects in recall. The causal network also predicted probability of recall; concepts with more links and concepts on the main causal chain were most likely to be recalled. This extends the causal network model to more complex materials than previous research.     

TACE联合RFA序贯DC-CIK治疗小肝癌的研究进展

射频消融术（RFA ）、肝动脉化疗栓塞术（TACE）及 DC-CIK 治疗等非手术方法已成为治疗小肝癌的重要手段。RFA 及 TACE 直接杀伤肿瘤细胞,DC-CIK 治疗明显改善机体免疫功能。 TACE 联合 RFA 术后序贯 DC-CIK 治疗可取长补短,提高治疗的有效性、安全性及患者的远期疗效。本文主要对 DC-CIK 治疗、TACE 、RFA 治疗现状及联合治疗前景做一综述。     

肺结核痰涂片阴性的试验性治疗应用探讨

本文通过对涂阴肺结核及试验性治疗相关概念的分析探讨,结合临床实际,认为试验性治疗不仅有利于涂阴肺结核的早期诊断和及时治疗,也是减少误诊、漏诊的主要措施。     

APPLICATIONS OF A SEQUENTIAL ALTERNATING TREATMENTS DESIGN

We propose the use of a combined version of the alternating treatments and multiple baseline designs in situations in which a traditional baseline (no treatment) condition either does not provide an adequate contrast condition or is not feasible or practical due to clinical constraints. We refer to this design as a sequential alternating treatments design because two treatments are initially implemented in a random or counterbalanced fashion and are followed by a sequential change in one or both treatments across settings, subjects, or tasks. The effects of the independent variables are assessed first by analyzing the two series of data points representing the different treatments (relative effects) and then by assessing changes in one or both series, as application of the alternative treatment is introduced sequentially. The sequential application of treatment provides an analysis of control in the same manner as the multiple baseline design; the initial alternating treatments phase provides a contrast condition in much the same manner as a baseline condition. Applications of this design to the assessment of peer training and self-injurious behavior are described.     

组织工程骨在口腔颌面部骨缺损中的应用与思考

组织工程已经开始应用于口腔医学领域,组织工程骨在治疗牙槽骨缺损,上颌骨及下颌骨缺损方面也取得了很大的进展,为颌面骨缺损的修复开辟了一条新途径,但同时也存在技术方面的不足和伦理学问题.     

A comparison of simultaneous versus sequential presentation of novel foods in the treatment of food selectivity

The present study extended the literature on feeding disorders by conducting a comparison of sequential and simultaneous food presentation in the treatment of food selectivity. In the simultaneous condition, a highly preferred food was presented in the same bite with a non‐preferred food (NPF), and during the sequential condition, a highly preferred food was delivered as a consequence for acceptance and consumption of NPFs. Generalization and maintenance of food consumption was assessed. Although results for two participants indicated that both presentation methods produced an increase in acceptance and consumption of NPFs when combined with an escape extinction procedure, anecdotal observations suggested that participants may have had a preference for eating foods in a sequential fashion. Copyright © 2010 John Wiley & Sons, Ltd.     

Information-processing differences and laterality of students from different colleges and disciplines

1023 college students were assessed for hemispheric brain dominance using the paper-and-pencil test, the Human Information Processing Survey. Analysis of scores of students majoring in Advertising, Interior Design, Music, Journalism, Art, Oral Communication, and Architecture suggested a preference for right-brain hemispheric processing, while scores of students majoring in Accounting, Management, Finance, Computer Science, Mathematics, Nursing, Funeral Service, Criminal Justice, and Elementary Education suggested a preference for left-hemispheric strategies for processing information. The differential effects of hemispheric processing in an educational system emphasizing the left-hemispheric activities of structured logic and sequential processing suggests repression of the intellectual development of those students who may be genetically favorable to right-hemispheric processing.