反馈对注意缺损多动障碍儿童错误监控能力的影响

研究选取了注意缺损多动障碍(ADHD)儿童39名,正常儿童40名,采用两项选择任务,考察在无反馈和有反馈的情况下,ADHD儿童的错误监控能力是否存在缺损。结果发现,(1)无论是否提供反馈,与正常儿童相比,ADHD儿童的错误察觉能力正常,但是错误更正能力落后,这可能是由于ADHD儿童动作调节控制能力落后导致的;(2)反馈提高了ADHD儿童和正常儿童的认知加工速度,但同时降低了他们的警醒水平,导致错误监控能力下降。     

未意识到错误影响错误后调整的电生理证据

现有研究一致认为意识到错误可引起错误后调整, 但是未意识到错误能否促使个体进行错误后调整尚存争议。本实验采用基于go/no-go范式的错误意识任务考察上述问题, 并根据被试对自己按键反应正误主观报告将no-go错误反应分为意识到错误和未意识到错误。行为结果发现, 意识到错误和未意识到错误后正确率均显著高于正确击中试次(正确go试次)后正确率; 但是, 意识到错误后试次反应时显著快于正确击中后反应时, 未意识到错误后反应时显著慢于正确击中后反应时。该结果表明两类错误均优化了错误后行为表现, 但是意识到错误后被试调整速度加快, 未意识到错误后被试调整速度减慢。进而, 时频分析发现意识到错误相较于未意识到错误诱发显著更强的alpha波能量。并且, 前者在错误意识主观报告前已诱发alpha波, 后者在错误意识主观报告反应后诱发alpha波。该结果表明意识到错误一直处于持续的注意监控中, 而未意识到错误是任务引起的暂时注意控制。因此, 本实验说明错误意识影响错误后调整, 意识到错误可能采用类似主动性控制的策略调节错误后行为, 而未意识到错误可能采用类似反应性控制的策略调节错误后行为。     

急性应激损伤错误监控与错误后调整

生活中, 个体会时时关注自己的行为结果并及时做出调整以适应环境的变化。但在应激下个体能否有效地监控行为并做出适应性调整依然未知。本研究招募了52名男性大学生被试, 将其随机分入应激组与控制组, 采用特里尔社会应激测试(Trier Social Stress Test, TSST)诱发个体的应激反应, 并结合错误意识任务(Error Awareness Task, EAT)探索个体急性应激下的错误监控与错误后调整过程。应激指标的结果显示应激组个体在应激任务后唾液皮质醇、心率、应激感知自我报告和负性情绪均显著高于控制组, 表明急性应激的诱发是成功的。行为结果显示应激组的错误意识正确率显著低于控制组, 错误意识反应时显著短于控制组; 进一步地, 应激组个体在意识到错误之后的试次上正确率显著低于未意识到错误之后的试次, 并且应激组个体在意识到错误之后的试次上正确率低于控制组。结果表明急性应激降低了个体对错误反应的监控水平, 即便在辨别出错误反应的情况下, 个体的行为监控与调节也更差。本研究说明急性应激会损伤行为监控系统, 导致个体的行为适应性下降。     

错误加工的神经机制

错误加工在认知控制和行为监控中起着关键的作用。监控自己的认知和行为结果,觉察到应该的反应和实际的反应之间的差别（即错误）,纠正这种错误并防止再犯是错误加工的主要内容。错误反应或由代表反应错误等负性反馈刺激诱发的ERP相对于正确反应或由代表反应正确等正性反馈刺激诱发的ERP,表现出一个相对负走向的波形变化,称为错误相关负波（error-related negativity, ERN）和反馈相关负波（feedback-related negativity, FRN）,两者都定位于前扣回附近。错误加工神经机制的研究主要集中于前扣回与ERN、错误意识与错误加工、ERN与FRN的关系。对于前扣带回和ERN的功能意义的解释主要有错误检测理论、冲突监控理论、强化学习理论和预期违反假说。目前错误加工神经机制的研究在研究内容、研究方法和理论观点等方面还存在些问题,这些可能是未来进一步的研究方向     

视觉监控作业中信号间隔时间和双任务对信号觉察的影响

本研究运用模拟实验,考察了以仪表显示为主的监控系统中信号间隔时间和双作业任务对人觉察信号的反应时间的影响.双作业中的主任务是要求被试同时监视4个仪表,次任务为对显示屏上一个红色亮点是否出现闪烁作简单的辨别反应.实验结果表明信号间隔时间是影响信号觉察反应时的一个重要因素.随着信号间隔时间由30-50秒延长到8-10分钟,信号觉察反应时随之先快后慢地增加.在低负荷的仪表监视作业中,通过增加一个刺激率较高而又比较简单的次任务,可使被试保持较高的唤醒水平和更好地集中注意,从而有利于提高信号觉察效率.     

激活水平对两亚型ADHD儿童反应执行与抑制能力的影响

研究选取了混合型ADHD儿童14名,注意缺陷型ADHD儿童16名以及正常儿童18名,考察了在不同激活水平下,两亚型ADHD儿童之间,及其与正常儿童之间的反应执行能力与抑制能力的异同。采用传统的go/no-go任务,并将刺激间的时间间隔设置为1秒、4秒、8秒三种条件,分别对应高、中、低三种激活水平。结果发现,(1)与正常儿童相比,ADHD儿童的反应执行能力更容易受到激活水平的影响,且两亚型ADHD儿童受到的影响模式基本一致。具体而言:在高激活水平下,ADHD儿童与正常儿童差异最小;在中、低激活水平下,ADHD儿童与正常儿童差异增大,表明ADHD儿童状态调节能力落后。(2)两亚型ADHD儿童的功能缺损模式不同,混合型儿童在状态调节和反应抑制两方面都存在缺损,且其反应抑制缺陷不受激活水平影响;注意缺陷型儿童仅在状态调节方面受损。     

联系可觉察度对错误记忆的影响

本研究采用DRM词表学习法和图片刺激对学习法两种研究范式考察了关键诱饵与学习项目间联系可觉察度对错误记忆的影响。结果显示,学习项目与关键诱饵的联系可觉察度对错误记忆起重要作用:在词表学习范式中,随着联系可觉察度的提高,被试觉察到的词表的关联性更高,错误记忆就更容易发生;在刺激对学习范式中,随着联系可觉察度的提高,学习项目和关键诱饵间的差异区分性提高,导致二者间的关联性降低,从而减少错误记忆。本研究为进一步揭示错误记忆的机制、更好地理解记忆及其机制提供了新的证据,并对如何提高记忆效率具有一定的实际应用价值。     

注意缺陷多动障碍儿童在不同加工阶段的干扰控制

采用刺激－刺激和刺激－反应相容性任务范式,将信息加工在知觉和反应阶段的冲突效应分离开来,考察注意缺陷多动障碍（Attention Deficit Hyperactivity Disorder,简称ADHD）儿童在知觉和反应阶段冲突控制的模式和时间轨迹。结果发现,在反应阶段,ADHD儿童的干扰控制能力明显弱于正常对照组儿童,混合型ADHD儿童的能力更弱于注意缺陷型ADHD儿童;在知觉阶段,ADHD儿童没有明显的干扰抑制缺损,两组ADHD儿童（注意缺陷型和混合型）的表现模式相似;儿童抑制冲突干扰所遵循的时间轨迹在知觉和反应阶段有所不同：与知觉阶段相比,反应阶段需要更长的时间才能抑制冲突干扰。但ADHD儿童和正常儿童之间的表现模式相似     

道德情绪判断、错误信念与行为问题的关系——损人情境中幼儿反应的一项研究

运用投射性情境故事和Rutter量表(教师问卷)研究了204名幼儿对损人情境的道德情绪判断、错误信念水平、行为问题及其关系。结果表明:(1)男性幼儿的违纪行为显著高于女性,神经症行为得分在不同年龄之间差异达到显著性水平。(2)随年龄增长,对成功损人者之情绪判断为积极的人数会减少、而判断为消极的人数会增加,对失败损人者之情绪判断为消极的居多、而对成功损人者情绪判断为积极的为主。(3)幼儿已经基本能完成道德情境中的错误信念任务,当接受别人的"错误"表扬时会产生积极情绪。(4)未完成错误信念任务儿童的神经症得分显著高于完成者,对成功损人者之情绪判断为积极的儿童的神经症得分显著高于判断为消极者。     

间隔时间及记忆负荷对信息缺失错误记忆的影响

现场中的信息缺失会影响人类对事件的记忆,这对证人证言研究是非常重要的,但以往对之却鲜有研究.本研究以大学生为被试,运用信息缺失范式,采用视频录像材料,通过2个实验探讨了间隔时间和记忆负荷对错误记忆的影响.结果表明:(1)间隔时间没有影响真实记忆和错误记忆,但信心水平却随着间隔时间的延长而变化;(2)记忆负荷高低没有影响真实记忆却影响了错误记忆,在关键信息呈现条件下,降低记忆负荷可以减少错误记忆的发生;(3)信息性质会影响人们的记忆,关键信息呈现条件下的错误记忆和真实记忆均高于关键信息缺失的条件.     

Evidence for an Error Monitoring Deficit in Attention Deficit Hyperactivity Disorder

We studied error monitoring in ADHD and control children in a task requiring inhibition of a motor response. The extent of slowing following successful (stopped) and failed (nonstopped) inhibition was compared across groups. We also measured the time required to inhibit a response (stop signal reaction time, SSRT). Compared to controls, ADHD participants slowed less following nonstopped responses. Slowing did not vary with comorbid reading, oppositional, conduct or anxiety disorder, sex or ADHD subtype. Slowing after nonstopped responses was marginally, although significantly correlated with total ADHD symptoms and with age. ADHD participants had significantly longer SSRT than controls, but SSRT was not significantly correlated with slowing. The apparent deficit in error monitoring in ADHD and its independence from the inhibition deficit observed in ADHD has implications for executive control models of ADHD, performance problems associated with the disorder and for component theories of executive control.     

两亚型注意缺陷多动障碍(ADHD)儿童的内隐注意定向

研究探讨注意缺陷障碍儿童与正常儿童之间,混合型与注意缺陷型ADHD儿童之间在内源与外源注意定向功能的差异。ADHD儿童及与之匹配的正常儿童对照组分别参与了两个实验,实验一采用了内源性内隐注意定向任务,实验二采用了外源性内隐注意定向任务。研究表明：（1）ADHD儿童与正常儿童相比,在注意定向过程（注意解除、转移与施加）上有一定缺陷。（2）ADHD儿童注意定向网络功能有缺陷,与反应水平上动作准备有关的注意功能可能受损。（3）两种亚类型儿童注意定向功能缺陷模式不同。在内原定向上,混合型与注意缺陷型相比较,混合型ADHD儿童表现为有较强的反应冲动性;注意缺陷型儿童,主要表现为注意加工过程比较缓慢,注意更易涣散。在外源定向上,混合型儿童在反应的运动准备及运动控制方面的缺陷要大于注意缺陷型儿童     

Cognitive Load Differentially Impacts Response Control in Girls and Boys with ADHD

Children with attention-deficit hyperactivity disorder (ADHD) consistently show impaired response control, including deficits in response inhibition and increased intrasubject variability (ISV) compared to typically-developing (TD) children. However, significantly less research has examined factors that may influence response control in individuals with ADHD, such as task or participant characteristics. The current study extends the literature by examining the impact of increasing cognitive demands on response control in a large sample of 81children with ADHD (40 girls) and 100 TD children (47 girls), ages 8–12 years. Participants completed a simple Go/No-Go (GNG) task with minimal cognitive demands, and a complex GNG task with increased cognitive load. Results showed that increasing cognitive load differentially impacted response control (commission error rate and tau, an ex-Gaussian measure of ISV) for girls, but not boys, with ADHD compared to same-sex TD children. Specifically, a sexually dimorphic pattern emerged such that boys with ADHD demonstrated higher commission error rate and tau on both the simple and complex GNG tasks as compared to TD boys, whereas girls with ADHD did not differ from TD girls on the simple GNG task, but showed higher commission error rate and tau on the complex GNG task. These findings suggest that task complexity influences response control in children with ADHD in a sexually dimorphic manner. The findings have substantive implications for the pathophysiology of ADHD in boys versus girls with ADHD.     

Time-based prospective memory difficulties in children with ADHD and the role of time perception and working memory

Time-based prospective memory (PM) is the ability to remember to perform an intended action at a given time in the future. It is a competence that is crucial for effective performance in everyday life and may be one of the main causes of problems for individuals who have difficulty in planning and organizing their life, such as children with attention deficit/hyperactivity disorder (ADHD). This study systematically examines different aspects of time-based PM performance in a task that involves taking an action at a given future time in a group of 23 children with ADHD who were compared with a matched group of typically-developing (TD) children. The children were asked to watch a cartoon and then answer a questionnaire about its content (ongoing task). They were also asked to press a key every 2 minutes while watching the cartoon (PM task). The relationships of time perception and verbal working memory with PM performance were examined by administering appropriate tasks. The results showed that the children with ADHD were less accurate than the TD children in the PM task and exhibited less strategic time-monitoring behavior. Time perception was found to predict PM accuracy, whereas working memory was mainly involved in time-monitoring behavior, but this applied more to the TD group than to the ADHD group, suggesting that children with ADHD are less able to use their cognitive resources when meeting a PM request.     

Time perception in boys with attention-deficit/hyperactivity disorder according to time duration, distraction and mode of presentation.

In a recent theoretical model of attention-deficit/hyperactivity disorder (ADHD), Barkley (1997a) predicted that ADHD children experience impairments in their psychological sense of time. This was demonstrated in a series of experiments by Barkley, Koplowicz, Anderson, and McMurray (1997). The present study sought to investigate the effects of ADHD subtype, stimulus duration, mode of presentation (visual versus auditory) and distractors on the performance of a simple time reproduction task. Data were obtained from 44 ADHD children (14 predominantly inattentive and 30 combined type) and 44 age-matched Controls using the Time Perception Application version 1.0 (Barkley, University of Massachusetts Medical Center, 1998). Results revealed that the ADHD children made significantly larger errors on Visual time reproduction tasks than the Controls, regardless of ADHD subtype or the presence of distractors. Furthermore, ADHD children were more likely to overestimate the shorter time intervals (0.5 and 2 s) and underestimate the longer time intervals (3, 4 and 6 s) relative to Controls. No group differences were observed on the auditory time reproduction task, with both ADHD and Control groups consistently underestimating the durations to be reproduced. The results of this study provide further support for the prediction that children with ADHD have an impaired sense of time.     

A trial-by-trial analysis reveals more intense physical activity is associated with better cognitive control performance in attention-deficit/hyperactivity disorder

Hyperactivity is a key symptom and the most observable manifestation of attention-deficit/hyperactivity disorder (ADHD). The over-activity associated with ADHD can cause specific challenges in academic settings, extracurricular activities and social relationships. Cognitive control challenges are also well established in ADHD. The current study included 44 children between the ages of 10 and 17 diagnosed with ADHD or who were typically developing (TD), all of whom had no psychiatric co-morbidity or significant learning disorders. Participants wore an actometer on their ankle while performing a flanker paradigm in order to objectively measure their rates of activity in association with cognitive control. Analyses assessed the relationship between frequency and intensity of activity to task accuracy on a trial-by-trial basis. A significant interaction effect between group and performance revealed that more intense movement was associated with better performance in the ADHD group but not in the TD group. The ADHD group demonstrated more intense activity than the TD group during correct (but not error) trials. Within-group, children with ADHD generated higher intensity movements in their correct trials compared to their error trials, whereas the TD group did not demonstrate any within-group differences. These findings suggest that excessive motoric activity associated with clinically significant ADHD symptoms may reflect compensatory efforts to modulate attention and alertness. Future research should systematically explore the relationship between motion in ADHD and how it might be used to improve cognitive performance.     

Can Motivation Normalize Working Memory and Task Persistence in Children with Attention-Deficit/Hyperactivity Disorder? The Effects of Money and Computer-Gaming

Visual-spatial Working Memory (WM) is the most impaired executive function in children with Attention-Deficit/Hyperactivity Disorder (ADHD). Some suggest that deficits in executive functioning are caused by motivational deficits. However, there are no studies that investigate the effects of motivation on the visual-spatial WM of children with- and without ADHD. Studies examining this in executive functions other than WM, show inconsistent results. These inconsistencies may be related to differences in the reinforcement used. The effects of different reinforcers on WM performance were investigated in 30 children with ADHD and 31 non-ADHD controls. A visual-spatial WM task was administered in four reinforcement conditions: Feedback-only, 1 euro, 10 euros, and a computer-game version of the task. In the Feedback-only condition, children with ADHD performed worse on the WM measure than controls. Although incentives significantly improved the WM performance of children with ADHD, even the strongest incentives (10 euros and Gaming) were unable to normalize their performance. Feedback-only provided sufficient reinforcement for controls to reach optimal performance, while children with ADHD required extra reinforcement. Only children with ADHD showed a decrease in performance over time. Importantly, the strongest incentives (10 euros and Gaming) normalized persistence of performance in these children, whereas 1 euro had no such effect. Both executive and motivational deficits give rise to visual-spatial WM deficits in ADHD. Problems with task-persistence in ADHD result from motivational deficits. In ADHD-reinforcement studies and clinical practice (e.g., assessment), reinforcement intensity can be a confounding factor and should be taken into account. Gaming can be a cost-effective way to maximize performance in ADHD.     

Perception of speech and nonspeech stimuli by children with and without reading disability and attention deficit hyperactivity disorder

The auditory temporal deficit hypothesis predicts that children with reading disability (RD) will exhibit deficits in the perception of speech and nonspeech acoustic stimuli in discrimination and temporal ordering tasks when the interstimulus interval (ISI) is short. Initial studies testing this hypothesis did not account for the potential presence of attention deficit hyperactivity disorder (ADHD). Temporal order judgment and discrimination tasks were administered to children with (1) RD/no-ADHD (n=38), (2) ADHD (n=29), (3) RD and ADHD (RD/ADHD; n=32), and (4) no impairment (NI; n=43). Contrary to predictions, children with RD showed no specific sensitivity to ISI and performed worse relative to children without RD on speech but not nonspeech tasks. Relationships between perceptual tasks and phonological processing measures were stronger and more consistent for speech than nonspeech stimuli. These results were independent of the presence of ADHD and suggest that children with RD have a deficit in phoneme perception that correlates with reading and phonological processing ability. (c) 2002 Elsevier Science (USA).     

阅读障碍与注意缺陷多动障碍儿童的语言加工和反应抑制

阅读障碍与注意缺陷多动障碍(ADHD)高度共病,以往研究结果显示两种障碍在语言加工、执行功能等领域的缺陷既相似又不同。本研究采用语音意识测验、快速命名测验、语素意识测验和停止信号任务,以及阅读广度测验,分别考察四组被试（阅读障碍组、ADHD组、双重障碍组、正常控制组）的基础语言加工、反应抑制和言语工作记忆能力,结果发现：阅读障碍组和双重障碍组在语言加工任务上的成绩均显著差于ADHD组和正常组;ADHD组和双重障碍组在停止信号任务上的成绩显著差于阅读障碍组和正常组;所有障碍组在阅读广度测验上的成绩显著差于正常组。表明阅读障碍的特异性缺陷体现在语言加工过程上,而注意缺陷多动障碍的特异性缺陷体现在反应抑制上。这对于今后单一障碍的研究及临床诊断和干预具有重要的参考价值。