幽门螺杆菌与胃癌关系的研究进展

幽门螺杆菌(H.pylori,Hp)是胃癌的发病因素之一,二者之间的关系非常密切。Hp感染蒙古沙土鼠成功诱发胃癌,在动物实验中直接证实Hp与胃癌发生有关。众多大规模的人群干预研究显示Hp感染可增加胃癌发病率,根除Hp后胃癌的发生有减少趋势;Hp毒力基因尤其是cag致病岛与胃癌发生关系密切。宿主反应基因尤其是前炎症细胞因子与胃癌的危险性增高有关。动物模型显示Hp诱导癌前病变的发生与上皮细胞周期的调控失常、细胞增殖与调亡的失衡相关。

The Research Progress in the Relationship between H. pylori and Gastric Cancer

H.pylori is one of the pathogenesis of gastric cancer. It is reported that spontaneous gastric adenocarcinoma in Mongolian gerbils infected with H.pylori, which proved that H.pylori infected is associated with gastric cancer in animal models. A series of interventional population investigation appear that H. pylori infected increase the risk of occurrence of gastric cancer and H. pylori eradication is able to reduce such risk. Virulence factors of H.pylori such as cag pathogenicity island determine the risk of gastric cancer. Host genetic factors especially pro-inflammatory cytokine can improve the risk of gastric cancer. The gastric pre-cancerous lesions induced with H.pylori in animal models showed that it is related to the epithelial cell cycle uncontrolled and imbalance between cell proliferation and apoptosis.