The Micro-Structure of Tapping Movements in Children

In order to investigate the development of movement speed in relation to movement organization, children of 5, 6, 7, 8 and 9 years of age and adults carried out a reciprocal tapping task, in which time pressure and distance were manipulated. The duration, velocity, acceleration and accuracy of the movements were compared between age groups. Age differences appeared mainly in the homing time, not in the duration of the distance covering movement phase. Accuracy and velocity of the distance covering movement phase differed with age. Time pressure affected the homing time, but not the duration of the distance covering phase. Distance manipulation affected mainly the velocity and duration of the distance covering movement phase and the homing time. In the discussion it is contended that age differences in homing time may be related to both the accuracy of the distance covering movement phase and the rate of information processing of the subject.     

Bilateral Transfer as a Function of Mental Imagery

Three experiments are reported which investigate the role of mental imagery in the bilateral transfer from right to left hand of rotary pursuit skill. In Experiment 1 both mental imagery and physical rehearsal showed significant positive transfer relative to a control condition. However, work decrement may have accumulated and transferred in the physical rehearsal group thereby depressing this group’s left-hand performance. Experiment 2 was conducted under conditions designed to allow work decrement to dissipate prior to transfer to the contralateral limb. The data still showed no difference between physical re-hearsal and mental imagery. One interpretation of these data is that work decrement was present under both the physical rehearsal and mental imagery manipulations in Experiment 1. The data from Experiment 3 confirmed this interpretation as well as replicated the positive transfer effects found for mental imagery in Experiments 1 and 2. The data are discussed in terms of central versus peripheral explanatory mechanisms.     

Human coffee drinking: manipulation of concentration and caffeine dose.

In a residential research ward coffee drinking was studied in 9 volunteer human subjects with histories of heavy coffee drinking. A series of five experiments was undertaken to characterize adlibitum coffee consumption and to investigate the effects of manipulating coffee concentration, caffeine dose per cup, and caffeine preloads prior to coffee drinking. Manipulations were double-blind and scheduled in randomized sequences across days. When cups of coffee were freely available, coffee drinking tended to be rather regularly spaced during the day with intercup intervals becoming progressively longer throughout the day; experimental manipulations showed that this lengthening of intercup intervals was not due to accumulating caffeine levels. Number of cups of coffee consumed was an inverted U-shaped function of both coffee concentration and caffeine dose per cup; however, coffee-concentration and dose-per-cup manipulations did not produce similar effects on other measures of coffee drinking (intercup interval, time to drink a cup, within-day distribution of cups). Caffeine preload produced dose-related decreases in number of cups consumed. As a whole, these experiments provide some limited evidence for both the suppressive and the reinforcing effects of caffeine on coffee consumption. Examination of total daily coffee and caffeine intake across experiments, however, provides no evidence for precise regulation (i.e., titration) of coffee or caffeine intake.     

Visuomotor contribution to force variability in the plantarflexor and dorsiflexor muscles

The visual correction employed during isometric contractions of large proximal muscles contributes variability to the descending command and alters fluctuations in muscle force. This study explored the contribution of visuomotor correction to isometric force fluctuations for the more distal dorsiflexor (DF) and plantarflexor (PF) muscles of the ankle. Twenty-one healthy adults performed steady isometric contractions with the DF and PF muscles both with (VIS) and without (NOVIS) visual feedback of the force. The target forces exerted ranged from 2.5% to 80% MVC. The standard deviation (SD) and coefficient of variation (CV) of force was measured from the detrended (drift removed) VIS and NOVIS steadiness trials. Removal of VIS reduced the CV of force by 19% overall. The reduction in fluctuations without VIS was significant across a large range of target forces and was more consistent for the PF than the DF muscles. Thus, visuomotor correction contributes to the variability of force during isometric contractions of the ankle dorsiflexors and plantarflexors.     

Interaction of Tremor and Magnification in a Motor Performance Task With Visual Feedback

In this study, the interaction between increased gain in the visual feedback loop and motor control of the periphery was investigated. Participants (N = 15) were asked to maintain a constant finger position while they used magnified visual feedback. The measure of the accuracy of each trial was the standard deviation (trial error) of the finger position. Trials performed under magnification had lower trial errors than trials without magnification. The change in trial error between trials with and without magnification proved greater than the difference between trials at any 2 magnifications. In contrast, the differences between individual subjects were often greater than the differences between performances at individual magnifications. At higher magnifications, performance seemed to be limited by the tremor; the ratio of trial error to tremor intensity was constant. When applied to microsurgery, the present results accord with those found in earlier research, including investigations that have found that the level of magnification used in microsurgery is not the most significant factor in achieving good results and that tremor is the limiting factor in microsurgical tasks.     

Recommendations from Multi-disciplinary Focus Groups on Cascade Testing and Genetic Counseling for Fragile X-associated Disorders

The purpose of this paper is to report the outcome of a collaborative project between the Fragile X Research and Treatment Center at the Medical Investigation of Neurodevelopmental Disorders (M.I.N.D.) Institute at the University of California at Davis, the National Fragile X Foundation (NFXF), and the Centers for Disease Control and Prevention (CDC). The objective of this collaboration was to develop and disseminate protocols for genetic counseling and cascade testing for the multiple disorders associated with the fragile X mental retardation 1 (FMR1) mutation. Over the last several years, there has been increasing insight into the phenotypic range associated with both the premutation and the full mutation of the FMR1 gene. To help develop recommendations related to screening for fragile X-associated disorders, four, two day advisory focus group meetings were conducted, each with a different theme. The four themes were: (1) fragile X-associated tremor/ataxia syndrome (FXTAS); (2) premature ovarian failure (POF) and reproductive endocrinology; (3) psychiatric, behavioral and psychological issues; and (4) population screening and related ethical issues.     

Lifespan changes in working memory in fragile X premutation males

Fragile X syndrome is the world’s most common hereditary cause of developmental delay in males and is now well characterized at the biological, brain and cognitive levels. The disorder is caused by the silencing of a single gene on the X chromosome, the FMR1 gene. The premutation (carrier) status, however, is less well documented but has an emerging literature that highlights a more subtle profile of executive cognitive deficiencies that mirror those reported in fully affected males. Rarely, however, has the issue of age-related declines in cognitive performance in premutation males been addressed. In the present study, we focus specifically on the cognitive domain of working memory and its subcomponents (verbal, spatial and central executive memory) and explore performance across a broad sample of premutation males aged 18–69 years matched on age and IQ to unaffected comparison males. We further tease apart the premutation status into those males with symptoms of the newly identified neurodegenerative disorder, the fragile X-associated tremor/ataxia syndrome (FXTAS) and those males currently symptom-free. Our findings indicate a specific vulnerability in premutation males on tasks that require simultaneous manipulation and storage of new information, so-called executive control of memory. Furthermore, this vulnerability appears to exist regardless of the presence of FXTAS symptoms. Males with FXTAS symptoms demonstrated a more general impairment encompassing phonological working memory in addition to central executive working memory. Among asymptomatic premutation males, we observed the novel finding of a relationship between increased CGG repeat size and impairment to central executive working memory.     

Reaction Time Methods in the Study of Motor Programming

Recent reaction time analysis of motor programming has utilized a precue stimulus that provides advance information about some or all of the attributes for the upcoming motor response. This kind of precue typically confounds the number of remaining stimuli with the motoric processes under investigation (Zelaznik, 1978). In Experiments 1 and 2 the precuing of hand, digit, and duration of a key press response was manipulated. A new precuing procedure was utilized that does not confound the number of stimuli with the motoric processes under investigation. The findings of Experiments 1 and 2 demonstrate that none of the advance information was helpful in reducing reaction time and as such, suggest that these features of movement are not selected in any particular order. Experiment 3 compared this new method of precuing to the older, traditional method. The results of this experiment suggested that there is parallel processing of the perceptual and motor mental operations in this reaction-time task, since there was an underadditive interaction between the number of stimulus response alternatives and the non-precued movement dimensions. This paper highlights problems inherent in the utilization of precuing methods to understand motor programming processes. It appears that a better understanding about the variables involved in movement control is necessary before examining the order of selection of those variables.