Predictive testing and oncogenes

Case vignette: sharing unanticipated genetic information. The Questor family has experienced an unusual number of malignancies in the past two generations and has been advised by an oncologist that the p53 oncogene known as Li-Fraumeni Syndrome may be present in the family genome. The option of predictive genetic testing has been raised and several branches of the family have chosen to undergo screening to determine whether they are at risk for cancer because of the gene. Roger and Liz Questor have arranged for screening of themselves and their three children, ages 12, 10, and 7. The couple has, by all appearances, been happily married for 14 years. None of the family members are found to carry the oncogene; however, the geneticist conducting the analyses has made an interesting incidental discovery. The 10-year-old child is not the biological progeny of Roger Questor. Although the 12- and 7-year-olds are clearly the biological children of the couple, it is evident that the 10-year-old born to Liz Questor was fathered by a person other than Roger. What are the ethical obligations of the geneticist with respect to any sharing or disclosure of the information that has been discovered incidentally? What course of action, if any, do you recommend?     

合作学习对小学生同伴关系、成就动机和成就影响的研究

旨在探讨在我国开展合作学习教学的可行性,以及合作学习对小学生同伴关系、成就动机和成就水平的影响,运用自然实验和测量相结合的方法,选择了北京师范大学实验小学三年级两个班进行实验研究,其中一个班为实验班（ｎ＝３５）,另一个班为控制班（ｎ＝３７）．实验为期三个月。结果表明：合作学习在小学教学中不但是可行的,而且效果较为显著;合作学习对同伴关系的改善有着积极的影响,学生间的接纳度和被接纳度都有普遍的提高;合作学习在较大程度上激发了学生的成就动机水平,学生对合作学习的课程兴趣明显提高．成绩较差的学生表现得更为明显;合作学习对提高学生的学习成绩有一定的促进作用。     

Differences in influence between pitched-from-vertical lines and slanted-from-frontal horizontal lines on egocentric localization

The visual field exerts powerful effects on egocentric spatial localization along both horizontal and vertical dimensions. Thus, (1) prism-produced visual pitch and visual slant generate similar mislocalizations of visually perceived eye level (VPEL) and visually perceived straight ahead (VPSA) and (2) in darkness curare-produced extraocular muscle paresis under eccentric gaze generates similar mislocalizations in VPEL and VPSA that are essentially eliminated by introducing a normal visual field. In the present experiments, however, a search for influences of real visual slant on VPSA to correspond to the influences of visual pitch on VPEL failed to find one. Although the elevation corresponding to VPEL changes linearly with the pitch of a visual field consisting of two isolated 66.5°-long pitched-from-vertical lines, the corresponding manipulation of change in the slant of either a horizontal two-line or a horizontal four-line visual field on VPSA did not occur. The average slope of the VPEL-versus-pitch function across 5 subjects was +0.40 over a ±30° pitch range, but was indistinguishable from 0.00 for the VPSA-versus-slant function over a ±30° slant range. Possible contributions to the difference between susceptibility of VPEL and VPSA to visual influence from extraretinal eye position information, gravity, and several retinal gradients are discussed.     

与年龄相关的认知速度减慢及学习改善过程

该工作应用人机对话方式完成心算、符号数字、数字鉴别和计数四项作业认知速度年老减慢及学习改善过程的研究,被试３５０人,４６—７５岁。研究结果表明：四项认知作业速度随年老进行性减慢;然而,老年人经学习训练认知作业速度可明显改善。上述变化程度与作业所需时间有密切关系,提示年老过程中枢信息加工过程速度的减慢快于外周感觉─运动过程速度的减慢,学习改善作用也可能主要是中枢过程速度的提高。     

非词语性认知作业速度年老衰减规律的数学描述

应用两维年龄多作业回归分析方法,研究了四项非词语性认知作业速度年老衰减规律的数学描述形式。被试共７３４名,４６─７５岁。结果表明：五个年老组与４６─５０岁组作业时间之间呈线性函数关系,其线性方程的斜率值随年老组的增龄而增大。     

关联性记忆错觉的产生与保持

两项实验对关联性记忆错觉的产生与保持进行了考察。实验结果表明,关联性记忆错觉接近学过词的回忆水平,但它的产生不随年龄的变化而变化;时间变量对关联性记忆错觉的影响不显著。此外,关联性记忆错觉不同于学过的词,在延迟加快时没有系列位置效应的产生。     

成人脑涨落图年龄变化特点的研究

该工作研究了１２０名２０－７９岁正常成人脑涨落图的年龄变化特点。结果表明：（１）从２０岁到５０岁,Ｓ系谱线活动向低频方向集中,６０岁后谱线又向高频方向有所移动;（２）部分谐振系的随龄变化表现明显,其中以Ｓ１７系变化最为敏感;（３）脑区间相干活动和各脑区的连频活动随年龄增强,脑能量分布的有序性逐渐破坏;（４）增龄性变化主要反映在优势脑区（左前脑）和优势脑轴（左前／右后脑）上,与脑高级机能活动密切相关的左前脑的退行性变化最为明显。上述结果反映了脑功能的减退是一个非线性的多层次的复杂过程。     

时序信息提取机制的探索

对时序信息加工的经典研究是采用新近性判断范型,结果发现其提取机制是以新近性为基础的逆向串行搜索过程。本研究采用新近性判断范型和早远性判断范型对时序信息的提取机制进行了深入的考察,结果表明：（ｌ）提取时序信息既存在逆向串行搜索,又存在顺向串行搜索;（２）早远性判断和新近性判断任务对不同部分时序信息恢复的效应不同,其中早远性判断易化早远部分,新近性判断易化新近部分──表现为对相应部分辨别力的提高和正确反应潜伏期的缩短;（３）在不同的时序信息提取任务中,被试会根据具体条件进行反转反应。     

The temporal structure of spoken sentence comprehension in Chinese

Three experiments with 60 native Chinese speakers were conducted to examine the temporal structure of spoken sentence comprehension in Chinese. In the two sentence-gating experiments, listeners heard sentence fragments of various sizes, either successively or individually, and decided on the agent role of the sentence. In the agent-naming experiment, listeners repeated aloud the sentence agent upon hearing the sentence. Converging evidence was derived from these experiments indicating the usefulness of sentence gating in tapping into the temporal structure of comprehension and in evaluating listeners’ comprehension on the basis of partial information. Results from these experiments show that partial sentence information plays a very important role in Chinese sentence comprehension, and that Chinese listeners integrate incomplete and ungrammatical sentence fragments by reference to complete and grammatical models in the language. It is argued that these processing characteristics reflect properties of the Chinese language in which few morphological, grammatical, and syntactic constraints are placed on the relationships between sentence constituents.     

关键词方法与英语词汇的掌握

本实验用中国学生对国外的学习外语词汇的关键词方法进行了验证。结果表明现有的关键词方法不适于中国学生,但改进了的新关键词方法明显地有利于学生均英译中。