Consolidation and translation regulation

mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.     

Exploring the Phenotype of Phonological Reading Disability as a Function of the Phonological Deficit Severity: Evidence from the Error Analysis Paradigm in Arabic

The dominant error types were investigated as a function of phonological processing (PP) deficit severity in four groups of impaired readers. For this aim, an error analysis paradigm distinguishing between four error types was used. The findings revealed that the different types of impaired readers were characterized by differing predominant error types. The dysphonetic errors predominated in readers with severe PP deficit and the morphological errors predominated in those with moderate deficits. Finally, readers with attention difficulties showed a predominance of semiphonetic errors. These findings were discussed in relation to reading disability subtypes and their clinical implications.     

Processing temporary syntactic ambiguity: the effect of contextual bias

This paper reports two experiments using sentences with a temporary ambiguity between a direct object and a sentence complement analysis that is resolved toward the normally preferred direct object analysis. Postverbal noun phrases in these sentences could be ambiguously attached as either a direct object or the subject of a sentence complement, whereas in unambiguous versions of the sentences the subcategorization of the verb forced the direct object interpretation. Participants read these sentences in relatively long paragraph contexts, where the context supported the direct object analysis ("preferred"), supported the sentence complement analysis ("unpreferred"), or provided conflicting evidence about both analyses ("conflicting"). Self-paced reading times for ambiguous postverbal noun phrases were almost equivalent to the reading times of their unambiguous counterparts, even in unpreferred and conflicted context conditions. However, time to read a following region, which forced the direct object interpretation, was affected by the interaction of verb subcategorization ambiguity and contextual support. The full pattern of results do not fit well with either an unelaborated single-analysis ("garden path") model or a competitive constraint-satisfaction model, but are consistent with a race model in which multiple factors affect the speed of constructing a single initial analysis.     

The Development of Reading and Spelling in Arabic Orthography: Two Parallel Processes?

The parallels between reading and spelling skills in Arabic were tested. One-hundred forty-three native Arab students, with typical reading development, from second, fourth, and sixth grades were tested with reading, spelling and orthographic decision tasks. The results indicated a full parallel between the reading and spelling performances within the second and fourth graders where the performance in the orthographic decision task was significantly lag behind. For the sixth graders, full parallel was found between the spelling and the orthographic decision performances with significant superiority of both performances on the reading performance. The results were discussed in light of developmental course of the orthographic representations and the impact of the specific orthographic features of the Arabic orthography on reading and spelling.     

Morphology and Spelling in Arabic: Development and Interface

In the current study, two experiments were carried out: the first tested the development of derivational root and word-pattern morphological awareness in Arabic; the second tested morphological processing in Arabic spelling. 143 Arabic native speaking children with normal reading skills in 2nd, 4th and 6th grade participated in the study. The results of the first experiment demonstrated the early emergence of derivational morphological awareness in children, with root awareness emerging earlier than word-pattern awareness. The second experiment supported the implication of morphological processing in spelling words and pseudo words across all grades tested. The results are discussed within a developmental psycholinguistic framework with particular emphasis on the characteristics of the Arabic language and orthography.     

Can physical activity be used as a tool to reduce depression in patients after a cardiac event? What is the evidence? A systematic literature study

A reduction in the incidence of cardiovascular diseases (CVD) has been reported in the Western world, but post‐infarction depression often occurs and is related to poor medical outcomes. The aim of this study was to examine the scientific literature by a systematic review, in order to find evidence for whether physical activity can be a tool to reduce depression in patients who have suffered a cardiac event. Three databases were systematically searched (PubMed, CINAHL, and Cochrane), and the GRADE protocol was used in combination with a revised Amstar‐protocol for the systematic review. Scientific reports fitting the area were scarce. Finally, ten studies were included in this study: one meta‐analysis, five randomized controlled trials, and four clinical trials. The results showed low to moderate evidence for the use of low to moderate levels of exercise as a tool to reduce depression in post‐coronary artery event patients. This study concluded positive effects of physical activity as a tool to reduce depression in post‐coronary artery event patients. Physiotherapists could be further involved in increasing physical activity after cardiac events. More studies are needed in the area.