如何实现慢性乙型肝炎的理性治疗

慢性乙型肝炎是一种常见的、严重危害人类健康的传染病.为了合理治疗慢性乙型肝炎病人,必须把握慢性乙型肝炎的治疗目标、治疗原则和恰当的治疗时机,明确如何选择恰当的药物.     

慢性乙型肝炎诊断和治疗方法学探讨

探讨慢性乙型肝炎诊断和治疗的方法学。仔细谨慎评价病毒载量等指标,客观准确地把握治疗时机,重视情绪障碍和营养不当,恰当选择抗病毒治疗方案。尽力形成慢性乙型肝炎诊断和治疗的完善方法系统。     

慢性乙型肝炎诊断和治疗方法学探讨

探讨慢性乙型肝炎诊断和治疗的方法学.仔细谨慎评价病毒载量等指标,客观准确地把握治疗时机,重视情绪障碍和营养不当,恰当选择抗病毒治疗方案.尽力形成慢性乙型肝炎诊断和治疗的完善方法系统.     

要重视慢性乙型肝炎的抗病毒治疗

慢性乙型肝炎是我国常见的慢性传染病之一,严重危害人民健康。围绕着乙型肝炎的防治,带来巨大的经济负担,已成为不可忽视的社会问题。在慢性乙型肝炎-肝硬化-HCC的发生发展过程中,HBV病毒载量起着重要的作用,抗病毒治疗是目前治疗慢性乙型肝炎的有效手段。因此,要重视和规范抗病毒治疗。     

干扰素治疗慢性乙型肝炎临床评价

干扰素治疗慢性乙型肝炎已有20多年历史,由于其抑制病毒复制和强大的免疫调节作用,以及具有疗程确定,不引起病毒变异耐药,显效后疗效持久的特点,是慢性乙型肝炎抗病毒治疗的首选药物之一。多项试验证明聚乙二醇化干扰素治疗慢性乙型肝炎的疗效优于普通干扰素和核苷类似物。本文就有关干扰素单用、联合核苷类似物和序贯疗法治疗慢性乙型肝炎的临床研究和HBV基因型对干扰素疗效的影响做简要综述。     

要重视慢性乙型肝炎的抗病毒治疗

慢性乙型肝炎是我国常见的慢性传染病之一,严重危害人民健康.围绕着乙型肝炎的防治,带来巨大的经济负担,已成为不可忽视的社会问题.在慢性乙型肝炎-肝硬化-HCC的发生发展过程中,HBV病毒载量起着重要的作用,抗病毒治疗是目前治疗慢性乙型肝炎的有效手段.因此,要重视和规范抗病毒治疗.     

非肝病治疗药物导致慢性乙型肝炎病毒携带者肝损害现状分析

随着药物种类的增多,药物性肝病的发病率亦增加。由于乙型肝炎病毒携带者肝组织已存在不同程度的损害,比非乙型肝炎病毒感染者更容易发生药物性肝炎。因此,非肝病治疗药物导致慢性乙型肝炎病毒携带者肝损害应引起高度重视。     

导言：重视慢性乙型肝炎特殊人群的抗病毒治疗

随着抗病毒药物包括聚乙二醇干扰素（PEG—IFN）和核苷（酸）类似物（NAs）在临床上的长期和广泛应用,加之我国慢性乙型肝炎防治指南的颁布和不断更新,同时肝病学会和感染病学会的专家对《指南》的广泛巡讲、解读,使包括基层医院在内的广大肝病工作者对慢性乙型肝炎抗病毒治疗的认识不断提高,越来越多的患者接受了抗病毒治疗。     

慢性乙型肝炎抗病毒治疗的进展

针对目前乙型肝炎的抗病毒治疗现状以及临床用药中存在的问题进行分析,就如何选择合理治疗方法提出医疗原则,认为对于慢性乙型肝炎的抗病毒治疗,应坚持联合治疗和个体化治疗,长期用药和间断反复用药结合,把病毒抑制到最低水平,以使发生原发性肝癌的可能性减至最小。     

非肝病治疗药物导致慢性乙型肝炎病毒携带者肝损害现状分析

随着药物种类的增多,药物性肝病的发病率亦增加.由于乙型肝炎病毒携带者肝组织已存在不同程度的损害,比非乙型肝炎病毒感染者更容易发生药物性肝炎.因此,非肝病治疗药物导致慢性乙型肝炎病毒携带者肝损害应引起高度重视.     

A joke is just a joke (except when it isn't): cavalier humor beliefs facilitate the expression of group dominance motives

Past research reveals preferences for disparaging humor directed toward disliked others. The group-dominance model of humor appreciation introduces the hypothesis that beyond initial outgroup attitudes, social dominance motives predict favorable reactions toward jokes targeting low-status outgroups through a subtle hierarchy-enhancing legitimizing myth: cavalier humor beliefs (CHB). CHB characterizes a lighthearted, less serious, uncritical, and nonchalant approach toward humor that dismisses potential harm to others. As expected, CHB incorporates both positive (affiliative) and negative (aggressive) humor functions that together mask biases, correlating positively with prejudices and prejudice-correlates (including social dominance orientation [SDO]; Study 1). Across 3 studies in Canada, SDO and CHB predicted favorable reactions toward jokes disparaging Mexicans (low-status outgroup). Neither individual difference predicted neutral (nonintergroup) joke reactions, despite the jokes being equally amusing and more inoffensive overall. In Study 2, joke content targeting Mexicans, Americans (high-status outgroup), and Canadians (high-status ingroup) was systematically controlled. Although Canadians preferred jokes labeled as anti-American overall, an underlying subtle pattern emerged at the individual-difference level: Only those higher in SDO appreciated those jokes labeled as anti-Mexican (reflecting social dominance motives). In all studies, SDO predicted favorable reactions toward low-status outgroup jokes almost entirely through heightened CHB, a subtle yet potent legitimatizing myth that "justifies" expressions of group dominance motives. In Study 3, a pretest-posttest design revealed the implications of this justification process: CHB contributes to trivializing outgroup jokes as inoffensive (harmless), subsequently contributing to postjoke prejudice. The implications for humor in intergroup contexts are considered.     

慢性乙型肝炎T细胞功能与HBV前C区变异的研究

通过研究慢性HBV感染者前C区变异及T细胞免疫功能与疾病的相关性,评估前C（preC）区变异及T细胞免疫功能对于慢性乙型肝炎（chronichepatitisB,CHB）预后的影响。分别采用实时荧光法、突变特异PCRmsPCR法及微粒酶免疫分析法对150例HBV-DNA阳性的CHB及50例健康体检者进行血清HBV-DN...     

Smoking is ok as long as I eat healthily: Compensatory Health Beliefs and their role for intentions and smoking within the Health Action Process Approach

Compensatory Health Beliefs (CHBs) are defined as beliefs that the negative consequences of unhealthy behaviours can be compensated for by engaging in healthy behaviours. CHBs have not yet been investigated within a framework of a behaviour change model, nor have they been investigated in detail regarding smoking. Thus, the aim of this study was to investigate on a theoretical basis whether smoking-specific CHBs, as a cognitive construct, add especially to the prediction of intention formation but also to changes in smoking behaviour over and above predictors specified by the Health Action Process Approach (HAPA). The sample comprised 385 adolescent smokers (mean age: 17.80). All HAPA-specific variables and a smoking-specific CHB scale were assessed twice, 4 months apart. Data were analysed using structural equation modelling. Smoking-specific CHBs were significantly negatively related to the intention to stop smoking over and above HAPA-specific predictors. Overall, 39% of variance in the intention to quit smoking was explained. For the prediction of smoking, CHBs were not able to explain variance over and above planning and self-efficacy. Thus, smoking-specific CHBs seem mainly important in predicting intentions but not behaviour. Overall, the findings contribute to the understanding of the role of smoking-specific CHBs within a health-behaviour change model.     

Chinese values in Singapore: Traditional and modern

A series of three studies was conducted to test the internal structure of the Chinese value hierarchy (CVH) in Singapore. Study 1 identified the empirically best–fit model with six factors: Prudence, Industry, Civic–Harmony, Moral Development, Social Power and Moderation. Relative magnitudes and interfactor correlations suggested that these factors could be further grouped into two superordinate clusters: (i) The Modern factor, with significantly higher magnitude, consisted of Prudence, Industry, Civic–Harmony and Moral Development; and (ii) the Tradition factor, with lower magnitude, consisted of Social Power and Moderation. Study 2 surveyed university students with differential preference for language usages: English or Chinese. Both language groups were equally high on the Modern factor, but the Chinese–language–preferred group showed a significantly higher endorsement for the Tradition factor, Chinese Worldview (CWV) and Chinese Health Beliefs (CHB). Further convergent validation for the Modern and the Tradition factors was provided by investigating their correlations with traditional Chinese beliefs and practices for the two language groups separately. Study 3 tested generation differences in CVH. University participants (Self) were compared with their parents (Parents) and friends (Friends). There were no differences between Self and Friends on both the Modern and Tradition factors, CWV and individual differences of modernity. Parents and Self did not differ on individual differences of modernity. Parents, however, were higher on the Modern factor, the Tradition factor and CWV. Results were discussed to support the concept of 'multiple modernity' (Tu, 1900) in Asian societies, and the 'revised convergence hypothesis' proposed by Yang (1988).     

Joy in the Midst of Suffering: Clowning as Care of the Spirit in Palliative Care

SUMMARY

We find joy in the midst of suffering at Daw House, a palliative care unit. Stories, ranging from moments of gentle tenderness to wild hilarity, speak of profound joy and of the courage of those who participate. We articulate some of the why and how of caring clowning. Clown Doctors aim to affirm people as people with richly storied lives, to give permission for both laughter and tears, and to bring consolation to the spirit. The art of clowning means that we seek to elevate people, to sensitively tailor music, touch, and colour to the interests of those we encounter, to invite a sense of wonder and spontaneity and to work to transform situations through the imagination.     

《周易》荣辱思想论要

《周易》中包含着丰富的知荣明耻患想。《周易》的荣辱观建立在天人合一的思想基础、等级宗法的社会基础、救世治乱的现实需求上。《周易》中的君子、小人分别是荣与辱的主体。《易经》的吉、凶、悔、吝、咎、亨、利、贞等断语体现了荣与辱的价值取向。《周易》荣辱思想主要表现为:以尚中时行为荣,以不节失恒为耻;以爱民德政为荣,以严苛刑狱为耻;以诚信友爱为荣,以失比争讼为耻;以治家严正为荣,以长幼失序为耻;以真情相爱为荣,以无爱婚姻为耻;以谨言慎行为荣,以躁言危行为耻等。     

“Bodyheartminding” (Xin 心): Reconceiving the Inner Self and the Outer World in the Language of Holographic Focus and Field

In this essay, inspired by the somatic turn in philosophy initiated by Richard Shusterman, I want to invoke the language of classical Confucian philosophy to think through the best efforts of William James and John Dewey to escape the mind-body and nature-nurture dualisms—that is, to offer an alternative vocabulary that might lend further clarity to the revolutionary insights of James and Dewey by appealing to the processual categories of Chinese cosmology. What I will try to do first is to refocus the pragmatist’s explanation of the relationship between mind and body through the lens of a process Confucian cosmology. And then, to make the case for James and Dewey, I will return to the radical, imagistic language they invoke to try and make the argument that this processual, holistic understanding of “vital bodyminding” is in fact what they were trying to say all along.     

Towards the conscientious development of ethical nanotechnology

Nanotechnology, the emerging capability of human beings to observe and organize matter at the atomic level, has captured the attention of the federal government, science and engineering communities, and the general public. Some proponents are referring to nanotechnology as “the next technological revolution”. Applications projected for this new evolution in technology span a broad range from the design and fabrication of new membranes, to improved fuel cells, to sophisticated medical prosthesis techniques, to tiny intelligent machines whose impact on humankind is unknowable. As with the appropriation of technological innovation generally, nanotechnology is likely to eventually bring dramatic and unpredictable new capabilities to human material existence, along with resulting ethical challenges and social changes to be reconciled. But as of yet, aside from a few simple new consumer goods, such as paint, rackets and fabric coatings, nanotechnology is undeveloped. Its social and ethical dimensions are not apparent. Even still, given the stated goals of the various nanotechnology initiatives to rearrange matter with increasing atomic precision, the impact of nanotechnology on human life and society is likely be profound. It is very difficult, however, to make accurate predictions about the future impact of nanotechnology development on humanity. At this time, the most important role for ethics analysis is to contribute to a humanitarian, conscientious approach to its development. This paper suggests that such an approach requires that attention be given to the roles of imagination, meaning-making, metaphor, myth and belief.