论从药品到毒品的“角色”转换

毒品与药品有着密不可分的联系,毒品来源于药品但又不同于药品。具有依赖性的药品一旦流入非管制渠道,用于非医疗目的,在社会上泛滥便成为毒品。因此,对有依赖性的药品需要严格管理并合理地使用。     

辩证认识氯胺酮

氯胺酮又称K粉,为苯环己哌啶的衍生物,非竞争性NMDA受体拮抗剂,起初作为分离性麻醉剂应用于临床,后因其具有致幻性和精神依赖性,作为一种新型毒品在世界范围内广泛流行.氯胺酮由药品变成毒品,引发了一系列哲学的思考,只有用发展的、辩证的、矛盾的哲学思维去认识氛胺酮,才能正确对待其被斌予的双重身份.     

辩证认识氯胺酮

氯胺酮又称K粉,为苯环己哌啶的衍生物,非竞争性NMDA受体拮抗剂,起初作为分离性麻醉剂应用于临床,后因其具有致幻性和精神依赖性,作为一种新型毒品在世界范围内广泛流行。氯胺酮由药品变成毒品,引发了一系列哲学的思考,只有用发展的、辩证的、矛盾的哲学思维去认识氯胺酮,才能正确对待其被赋予的双重身份。     

"医药分业"改革的经济学分析

目前,我国药品监督管理机构正在推行"渐进式的医药分业"政策,目标是将药品价格总体下降26%～30%,将每年469亿元～547亿元的药品毛利化作医疗服务收费标准的调整幅度,以后医疗服务收费标准按物价指数逐年调整.但在现有条件下执行这一政策,表面上医疗机构是直接的利益受损者,但事实上广大的药品消费者或支付者将为之埋单而成为利益受损者,药品生产者和流通渠道才是这一政策的真正受益者,政府也将面临提高医疗服务收费标准或增加医疗机构补偿的两难抉择.     

药价"虚高":成因、结果分析与对策探讨

药品价格"虚高"已成为近年来药品市场中的一个突出问题.通过考量药价"虚高"的成因,并从实证的角度分析药价"虚高"的结果--"有效需求人数"和"消费者剩余"的减少,提出一些建议.     

手术戒毒:"非常规"医疗探索下的社会视阈

"手术戒毒"是以一种"非常规"的方式毁损一部分人脑记忆和意识,来探索戒断毒瘾的有效途径."非常规"的手术戒毒挑战了长久以来公众对毒品的"常规"认识以及现行的戒毒政策和方法,从技术、伦理以及观念、权益、法律规制和政策支持等社会层面考量了这一项"非常规"手术.     

压力、感恩和基本心理需要满足对工读生毒品使用的影响机制

采用压力性生活事件量表、感恩问卷、基本心理需要量表、毒品使用问卷对585名工读生进行调查,分析了工读生毒品使用情况,以及压力性生活事件、感恩、基本心理需要满足与工读生毒品使用的关系。结果显示:(1)工读生的毒品使用行为严重,41.7%的工读生曾使用过毒品;(2)基本心理需要满足在压力性生活事件与毒品使用之间具有完全中介作用;(3)感恩调节了压力性生活事件通过基本心理需要满足对毒品使用的中介过程;(4)感恩与工读生的毒品使用显著负相关。研究结论对青少年毒品使用的预防干预有重要参考价值。     

毒品注射致假性股动脉瘤的手术并发症和愈合不良的分析

探讨毒品注射导致假性股动脉瘤(femoral false aneurysm,FFA)的术后合并症或愈合不良的原因.分析10年来46例毒品导致FFA的围手术期并发症和愈合不良情况.结果46例患者中,髂股动脉缝扎后4例患肢缺血,1例人工血管感染,4例切口淋巴瘘,1例惠肢肿胀,2例深静脉血栓,2例患肢麻痹,均经相应处理后好转.因此,综合评估毒品导致的FFA患肢的血供和假瘤,个体化选择手术方案.可减少术后并发症以及愈合不良.     

吸毒者如何根除“心瘾”

吸毒者吸毒成瘾后,心理上会反复出现无论如何都要感受吸毒所带来的那种快慰的强烈欲望,这种心理欲望医学上称之为心瘾。因此吸毒者通过戒毒治愈后,仍难以摆脱毒瘾的纠缠。据报道,吸毒人员通过强制戒毒成功后,复吸率高达80％以上。 有关专家认为,吸毒者对毒品具有强烈的心理依赖性。特别是可卡因、海洛因和冰毒等进入人体后,     

感觉寻求对工读生毒品使用的影响：有中介的调节效应

以523名工读生为调查对象,考察工读生毒品使用特点,并在控制相关人口学变量后,探讨感觉寻求、压力性生活事件、结交不良同伴与工读生毒品使用的关系。结果显示：（1）工读生的毒品使用行为严重,34.2%的工读生曾使用过毒品,毒品使用呈现低龄化、以吸食新型毒品为主的趋势。（2）工读生的感觉寻求是毒品使用的风险因素。（3）压力性生活事件对感觉寻求与毒品使用之间的关系具有风险增强的调节效应。（4）这种调节效应以结交不良同伴为中介变量。因此,感觉寻求对工读生毒品使用的影响是有中介的调节效应。研究结果对青少年毒品使用的预防和干预有重要的理论价值和参考价值。     

Drug Tolerance, Drug Addiction, and Drug Anticipation

ABSTRACT— Environmental cues associated with drugs often elicit withdrawal symptoms and relapse to drug use. Such cues also modulate drug tolerance. The contribution of drug-associated stimuli to withdrawal and tolerance is emphasized in a Pavlovian-conditioning analysis of drug administration. Conditional responses occur in the presence of cues that have been associated with the drug in the past, such as the setting in which the drug was taken. These conditional responses mediate the expression of tolerance and withdrawal symptoms. Recently, it has become apparent that internal predrug cues, as well as environmental cues, elicit pharmacological conditional responses that contribute to tolerance and withdrawal. Such internal cues include cognitive or proprioceptive cues incidental to self-administration, drug-onset cues that are experienced shortly after administration, and emotional cues. According to the conditioning analysis, addiction treatment should incorporate learning principles to extinguish the association between stimuli (environmental and internal) present at the time of drug administration and the effects of the addictive drug.     

Drug Use History, Drug Test Consequences, and the Perceived Fairness of Organizational Drug Testing Programs

We explored the effects of drug use history (current/recent user of drugs, used/tried drugs, never tried drugs) and a measure of drug test consequences (termination versus rehabilitation) on the perceived fairness of organizational drug testing (DT). Data were collected as part of a statewide telephone survey of the general adult population. Personal drug use history and DT consequences interacted such that DT consequences were related to DT fairness only for nonusers who had past drug use experience. The importance of past drug use in understanding reactions to DT are discussed.     

Social Categorization and the Influence of Drug Involvement on Drug Attitude Structures: Implications for Assessing Drug Use and Tolerance in the Workplace1

Theories of social categorization were used to generate hypotheses concerning the impact of drug involvement on the attitudes and knowledge structures that people use in making drug-related judgments. Data indicated that greater drug exposure tended to foster more complex knowledge structures for drugs and drug users as revealed by subjects’ perceptions of drug users, tolerance for drug use, and perceptions of drug seriousness. Basically, high drug involvement in terms of personal alcohol use and associating with illicit drug users was related to greater individuation of drug user types. Therefore, high-involved subjects, relative to low-involved individuals, were better able to discriminate between different drug user subtypes and drug user subtypes were more important to high-involved subjects when responding to drug-related survey items.     

Drug Abuse in the Sales Force

Drug abuse in the workplace is a national problem of frightening proportions and there is no reason to suspect that the nations's sales forces should be immune. This study examines the problem of sales force drug abuse and reports the findings of a nationwide survey of field sales managers concerning the extent of drug abuse in the nation's sales forces, the methods of dealing with the problem, and factors related to drug abuse problems in the sales force. Implications for sales managers, sales management educators and trainers, and researchers in the field of sales and sales management are also discussed.     

Drug postulate of Eysenck in the rat

The present work is an attempt to investigate the Drug Postulate of Eysenck in the animal field. The Ss were 36 male Wistar rats. The extraversion measure used was animal ambulation in a low-frightening open-field. d-Amphetamine, reserpine and saline were administered before the extinction of a lever-press FR 25 schedule for food. The results show that reserpine produces a decrement in the resistance to extinction (RExt), while d-amphetamine produces a biphasic effect, increasing the RExt in high-ambulatory (extravert) rats and leaving the RExt of low-ambulatory (introvert) rats unaffected. Therefore, reserpine acted as a depressant drug, d-amphetamine as a stimulant drug and ambulation as extraversion.     

抗血管生成靶向药物相关性高血压

高血压是抗血管生成靶向药物最常见的副作用之一,其机制和管理受到重视.本文就靶向药物导致高血压的机制进行了探讨,考虑可能与抗血管生成药物的作用靶点有关,即影响了血管内皮生长因子的功能所致;介绍临床如何进行高血压管理并建议在抗血管生成靶向药物使用过程中规范地监测、控制血压,开展相关研究.     

传统药物治疗认识误区几点浅析

药物是治疗疾病的物质基础,传统药物治疗认识中的许多误区影响人们对疾病的合理治疗.积极宣传药物治疗新理念,普及现代药学知识和理论,提高广大人民群众对药物治疗的认识水平,是避免出现药物治疗认识误区的主要手段.应加强宣传力度,带领群众走出误区,促进合理用药.