慢性乙型肝炎的联合抗病毒治疗可以降低核苷类药物的耐药率

慢性乙型肝炎是一种很难治愈的疾病，需要长期治疗以抑制病毒的复制，改善预后。现有的核苷（酸）类药物有较强的抗病毒效果，但在长期治疗过程中，容易发生病毒的耐药突变。多种药物的联合治疗可有效降低核苷（酸）类药物的耐药率，有助于长期治疗。

Combination Therapy of Chronic Hepatitis B Could Lower the Resistance of Nucleos （t）ide Analogues

Chronic hepatitis B is very difficult to be cured,and need a long term treatment to in-hibit viral replication and improve the prognosis. The nucleos （t） ides licensed have been proved to be potent in anti--viral treatment,but most of them have a high rate of viral resistance in prolonged usage. Combination therapy with multi--drugs can efficiently lower the occurrence of viral resistance,and may be helpful to long--term treatment.