The effect of imipramine and trazodone on the re-uptake of (3H) serotonin by thrombocytes in patients with endogenous depression: changes in antidepressive therapy |
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| Authors: | A B Katasonow O S Brusow B S Beljaew G P Slobina M I Faktor T B Larionowa K Trunte R R Lidemann |
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| Institution: | Institut für Klinische Psychiatrie, Akademie der Medizinischen Wissenschaften der UdSSR. |
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| Abstract: | The inhibitory potencies of imipramine (IC50-values for IMI) and trazodone (IC50-values for TRA) on platelet 3H]serotonin uptake were measured in depressed patients. The IC50-values for IMI in patients was shown to be higher (P less than 0.01) than in controls. The IC50-values for TRA in patients were lower (P less than 0.01) than found in platelets from controls. These alterations were not accompanied by the significant decrease of a density of platelet 3H]imipramine binding sites. Drug treatment led to the normalization of the IC50-values for IMI and to the partial increase of the IC50-values for TRA. There was a negative correlation of IC50-values for TRA and severity of depressive symptoms evaluated by the Hamilton Depression Rating Scale. The results support the hypothesis that the mechanisms of the regulation of 3H]serotonin uptake sensitivity to IMI and TRA in patients are different. |
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