Working memory consolidation is abnormally slow in schizophrenia |
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Authors: | Fuller Rebecca L Luck Steven J McMahon Robert P Gold James M |
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Institution: | Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA. bfuller@mprc.umaryland.edu |
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Abstract: | This study reports evidence that patients with schizophrenia demonstrate a slowing of working memory (WM) consolidation, which is the process of transforming transient perceptual representations into durable WM representations. Sixteen schizophrenia patients and 16 healthy control participants performed a task measuring the visual WM consolidation rate in a change-detection paradigm. A target display containing 3 colored squares was followed by a variable delay of 17-483 ms, a pattern mask, and then a test stimulus. This pattern mask does not interfere with perception but disrupts WM consolidation. Control participants reached no-mask performance by 250 ms, indicating completed WM consolidation, whereas patients failed to reach no-mask performance by 483 ms. Slowed consolidation may play an important and largely unrecognized role in schizophrenia. |
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