| 从抗原提呈细胞到抗原提呈小体 |
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| 引用本文： | 张红梅 张利旺 刘文超. 从抗原提呈细胞到抗原提呈小体[J]. 医学与哲学(人文社会医学版), 2006, 27(7): 50-52 |
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| 作者姓名： | 张红梅 张利旺 刘文超 |
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| 作者单位： | 第四军医大学西京医院肿瘤科 西安710032 |
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| 基金项目： | 2006全军医药卫生科研基金资助项目,项目编号：06MA205 |
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| 摘 要： | 树突状细胞是体内专职抗原提呈细胞,在抗肿瘤免疫治疗中发挥重要作用。而exosome是树突状细胞分泌的一种膜性微囊小体,富含树突状细胞的MHC-I/II类分子、协同刺激分子等多种生物活性分子,亦在抗肿瘤免疫应答中发挥重要作用。从树突状细胞到exosome,是细胞性瘤苗向非细胞性瘤苗的飞跃,对免疫治疗研究产生极为深远的影响。
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| 关 键 词： | Exosome 树突状细胞 免疫治疗 |
| 文章编号： | 1002-0772（2006）07-0050-03 |
| 收稿时间： | 2006-04-10 |
| 修稿时间： | 2006-04-102006-07-03 |
From Antigen Presenting Cells to Antigen Presenting Vesicles:philosophic thinking on cancer immunotherapy |
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| ZHANG Hong- mei ,ZHANG Li-wang, LIU Wen-Chao.. From Antigen Presenting Cells to Antigen Presenting Vesicles:philosophic thinking on cancer immunotherapy[J]. Medicine & Philosophy:Humanistic & Social Medicine Edition, 2006, 27(7): 50-52 |
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| Authors: | ZHANG Hong- mei ZHANG Li-wang LIU Wen-Chao. |
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| Abstract: | Dendritic cells (DC) are professional antigen presenting cells and play an important role in initiating anti-tumor immune responses. Exosomes are small membrane-bound vesicles secreted by dendritic cells, and are involved in different biological functions. Exosomes are enriched in MHC class I, II complexes and co-stimulatory molecules, and are of importance of anti-tumor immune response in vivo and in vitro. From antigen presenting cells to cell-free antigen presenting vesicles, great changes have taken place in cancer immunotherapy |
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| Keywords: | exosomes dendritic cell immunotherapy |
| 本文献已被 CNKI 维普 等数据库收录！ |
