Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained |
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Authors: | Rodriguez-Ortiz Carlos J De la Cruz Vanesa Gutiérrez Ranier Bermudez-Rattoni Federico |
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Affiliation: | Departamento de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., 04510, México. |
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Abstract: | Consolidation theory proposes that through the synthesis of new proteins recently acquired memories are strengthened over time into a stable long-term memory trace. However, evidence has accumulated suggesting that retrieved memory is susceptible to disruption, seeming to consolidate again (reconsolidate) to be retained in long-term storage. Here we show that intracortical blockade of protein synthesis in the gustatory cortex after retrieval of taste-recognition memory disrupts previously consolidated memory to a restricted degree only if the experience is updated. Our results suggest that retrieved memory can be modified as part of a mechanism for incorporating updated information into previously consolidated memory. |
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