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预期错误与急性应激对不同强度恐惧记忆提取消退的影响
引用本文:李俊娇,陈伟,胡琰健,曹杨婧文,郑希付.预期错误与急性应激对不同强度恐惧记忆提取消退的影响[J].心理学报,2021,53(6):587-602.
作者姓名:李俊娇  陈伟  胡琰健  曹杨婧文  郑希付
作者单位:1.广东第二师范学院教师教育学院, 广州 510303;2.华南师范大学心理学院;3.华南师范大学心理应用研究中心, 广州 510631;4.广东省心理健康与认知科学重点实验室, 广州 510631;5.东莞市东莞中学, 东莞 523120;6.西安外国语大学学生心理健康教育中心, 西安 710128
基金项目:国家自然科学基金项目(32000752);国家自然科学基金项目(31771218);国家自然科学基金项目(31970996);教育部人文社会科学研究项目(20YJC190009);广东省哲学社会科学规划项目(GD19YXL01);幸福广州心理服务与辅导基地, 广东省普通高校哲学社会科学重点实验室(2020WSYS002)
摘    要:在条件性恐惧记忆再巩固模型下, 预期错误被证明是引发记忆不稳定的必要条件, 但其在不同强度恐惧记忆下的作用尚不明确。对于高强度可能导致的提取无效, 缺乏相应的探索以寻找解决办法, 而应激(stress)在其中发挥的作用值得探索。本研究考察人类被试中, 预期错误在不同强度恐惧记忆下的作用, 以及提取之后施加外源性应激对于消退进程的影响。结果发现, 对于较弱的恐惧记忆, 单个预期错误提取后消退可显著抑制恐惧自发恢复; 而对于较强恐惧记忆, 单个预期错误不能提取恐惧记忆进入再巩固, 已消退的记忆还会复发; 且在该种情况下, 如果在提取后施加外源性急性应激, 会进一步增大恐惧恢复。

关 键 词:条件性恐惧  提取消退  预期错误  急性应激  记忆强度  
收稿时间:2020-02-27

Effects of prediction error and acute stress on retrieval-extinction of fear memories of different strengths
LI Junjiao,CHEN Wei,HU Yanjian,CAOYANG Jingwen,ZHENG Xifu.Effects of prediction error and acute stress on retrieval-extinction of fear memories of different strengths[J].Acta Psychologica Sinica,2021,53(6):587-602.
Authors:LI Junjiao  CHEN Wei  HU Yanjian  CAOYANG Jingwen  ZHENG Xifu
Abstract:Under the framework of Reconsolidation Interference of conditioned fear memory, Prediction Error (PE) has been demonstrated as a necessary condition of memory destabilization. However, the role of PE in destabilizing fear memories of different strengths is unclear. The degree of PE that is needed to effectively reactivate fear memories may be dependent on the strength of memory. It is unknown whether the PE used to reactivate weak memories is also effective in destabilizing stronger memories. Memory strength was proved to be an important boundary condition of memory reconsolidation; however, explorations of solutions to overcome the boundary are rare. Among factors that are possible to help to overcome the boundary condition, the effects of stress hormones are worth exploring. However, the manipulation of memory strength in human laboratory studies has not been well developed. Thus, the present study has three main aims: (1) to test the effect of fear memory strength in a human laboratory setting based on previous results in animal studies; (2) to examine the effect of PE during reactivation on destabilizing different strength memories and (3) to test the possible influence of post-reactivation exogenous stress to the retrieval-extinction of fear memories.
Keywords:conditioned fear  retrieval-extinction  prediction error  acute stress  memory strength  
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