首页 | 本学科首页   官方微博 | 高级检索  
     


Cognitive Functioning in Aging and Dementia: The Kungsholmen Project
Authors:Lars Bäckman  Åke Wahlin  Brent J. Small  Agneta Herlitz  Bengt Winblad  Laura Fratiglioni
Affiliation:1. Aging Research Center, Division of Geriatric Epidemiology , NEUROTEC, Karolinska Institute, and Stockholm Gerontology Research Center , Stockholm, Sweden;2. Aging Research Center, Division of Geriatric Epidemiology , NEUROTEC, Karolinska Institute, and Stockholm Gerontology Research Center , Stockholm, Sweden;3. Department of Psychology , Stockholm University , Stockholm, Sweden;4. Department of Gerontology , University of South Florida , Tampa, USA
Abstract:The Kungsholmen Project (KP) is a community-based longitudinal study of aging and dementia targeting the 75+ population. In this article, we review empirical studies with a cognitive focus from the KP. The main findings indicate that (a) there is an age-related decline for some cognitive domains (e.g., episodic memory, verbal fluency, visuoconstructive skill, psychomotor speed), but not for others (e.g., primary memory, visuoperceptive skill, motor-hand coordination), (b) multiple individual-difference variables within demographic (e.g., sex, education) life-style (e.g., activity levels), genetic (e.g., apolipoprotein E genotype), and health-related (e.g., vitamin B deficiency, depression, diabetes) domains are related to late-life cognitive functioning, (c) a potential for improving cognitive performance – a reserve capacity – is present also among very old adults, (d) the 2 most common dementia diseases, Alzheimer’s disease (AD) and vascular dementia (VaD), affect cognition in a strikingly similar manner, (e) the role of individual-difference variables in cognitive functioning is markedly reduced in dementia – the pathogenesis itself may overshadow the influence of other variables, and (f) there is a long preclinical period in dementia during which cognitive deficits are detectable. As is true with the other projects represented in this issue, the KP portrays a rather diversified picture of cognitive aging, although systematic patterns are evident with regard to the variability of late-life cognitive functioning.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号