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Neurodevelopmental influences in the genesis and epigenesis of schizophrenia: An overview
Authors:Tyrone D. Cannon  
Affiliation:University of Pennsylvania, USA
Abstract:The classical view of schizophrenia as a dementing disorder has recently been challenged by several findings pointing to a prenatal/perinatal origin of at least some of the brain abnormalities seen in these patients. This article reviews evidence from a number of different fields, including postmortem neuropathology, in vivo neuroimaging, developmental neuropsychology, and obstetric epidemiology in assessing the viability of a neurodevelopmental perspective of schizophrenia. Although the case for viewing schizophrenia as a neurodevelopmental condition is still circumstantial, and several gaps in this model remain, evidence from these diverse lines of inquiry converge to indicate at least a partial role of disturbances of brain development in the disorder's genesis and epigenesis.
Keywords:Brain development   Brain imaging   Genetics   Obstetric complications   Neuropathology   Neuropsychology   Schizophrenia
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