Structure and Etiology of Co-occurring Internalizing and Externalizing Disorders in Adolescents |
| |
Authors: | Victoria E. Cosgrove Soo H. Rhee Heather L. Gelhorn Debra Boeldt Robin C. Corley Marissa A. Ehringer Susan E. Young John K. Hewitt |
| |
Affiliation: | (1) Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA;(2) Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA;(3) Division of Substance Dependence, Department of Psychiatry, University of Colorado Denver Health Sciences Programs, Denver, CO, USA;(4) Department of Integrative Physiology, University of Colorado, Boulder, CO, USA;(5) VA Palo Alto Health Care System, Stanford University School of Medicine, 3801 Miranda Avenue (151T), Palo Alto, CA 94304, USA |
| |
Abstract: | Several studies suggest that a two-factor model positing internalizing and externalizing factors explains the interrelationships among psychiatric disorders. However, it is unclear whether the covariation between internalizing and externalizing disorders is due to common genetic or environmental influences. We examined whether a model positing two latent factors, internalizing and externalizing, explained the interrelationships among six psychiatric disorders (major depressive disorder, generalized anxiety disorder, separation anxiety disorder, attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder) in adolescents, and whether there are common genetic and environmental influences on internalizing and externalizing latent factors. Multivariate behavior genetic analyses of data from 1162 twin pairs and 426 siblings ascertained from the general population via the Colorado Center for Antisocial Drug Dependence (CADD) were conducted. We found support for a model positing two latent factors (internalizing and externalizing). These factors were moderately heritable and influenced by significant common genetic and nonshared environmental influences. These findings suggest that co-occurrence of internalizing and externalizing psychopathology in adolescents results from both genetic and environmental influences. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|