Serotoninergic regulation of emotional and behavioural control processes |
| |
Authors: | Cools Roshan Roberts Angela C Robbins Trevor W |
| |
Institution: | F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. roshan.cools@fcdonders.ru.nl |
| |
Abstract: | 5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|