Neophobia in spontaneous hypertensive (SHR) and normotensive control (WKY) rats |
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| Authors: | A Delini-Stula C Hunn |
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| Affiliation: | 1. MiraVista Diagnostics, 4705 Decatur Boulevard, Indianapolis, IN 46241, USA;2. Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA;3. Division of Infectious Diseases, University of Kansas, 3901 Rainbow Boulevard, Mailstop 1028, Kansas City, KS 66160, USA;4. Washington University School of Medicine, 660 South Euclid Avenue, Box 8051, Saint Louis, MO 63110, USA;5. Division of Clinical Microbiology, Department of Pathology and Laboratory Medicine, IU Health Pathology Laboratory, Indiana University School of Medicine, 350 West 11th Street, Indianapolis, IN 46202, USA;6. Methodist Professional Center-1, Suite 230, 1801 N Senate Boulevard, Indianapolis, IN 46202, USA;1. Huazhong University of Science and Technology, Wuhan, China;2. TU Dresden, Chair of Business Management, esp. Industrial Management, Germany;3. WHU, Otto Beisheim School of Management, Vallendar, Germany;1. Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing 100083, China;2. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China;3. Research Center for Bioengineering and Sensing Technology, Department of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100083, China;1. Department of Environmental Analytical Chemistry, Institute of Analytical Chemistry of the Czech Academy of Sciences, Veveří 97, 602 00, Brno, Czech Republic;2. Energy Research Center, VSB – Technical University of Ostrava, 17. Listopadu 2172/15, 708 00, Ostrava-Poruba, Czech Republic |
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| Abstract: | Latency of approaching a novel object (white-colored cube) placed in an unfamiliar open field, duration of object exploration, ambulation, rearing, grooming, and defecation were investigated in spontaneous hypertensive rats (SHR), their genetic normotensive controls (WKY), and standard Laboratory rats of Wistar origin (Tif:RAIf). The parameters measured were taken as indices of fear due to novelty (neophobia). Remarkable differences in behavior of all three strains were observed. By comparison to RAIf and WKY rats, SHR showed decreased neophobia as reflected in the significantly shorter latency of approaching the object and enhanced ambulation and rearing activity in the open field. By comparison to RAIf rats SHR also showed reduced grooming and defecation. WKY rats distinguished themselves from both SHR and RAIf by almost total absence of all responses in this test situation. This behavioral suppression was antagonized by 7.5 mg/kg ip of chlordiazepoxide. The results of this study further support the notion that, by comparison to standard laboratory rats, both SHR and WKY rats show possible genetically determined, altered behaviors which are diametrically opposite to each other. |
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