心肌缺血再灌注损伤治疗新策略——胆碱能抗炎通路

缺血再灌注损伤（ischemia／reperfusion injury，IRI）是在组织器官缺血恢复血流后，细胞代谢功能障碍及结构破坏反而加重的现象。炎症及其介质可诱发、加重心肌缺血再灌注损伤，已证明与其关系密切。胆碱能抗炎通路是新发现的一条与神经免疫机制相关的抗炎通路，通过分泌乙酰胆碱，抑制炎症因子释放，为防治心肌缺血再灌注损伤提供新的治疗策略。

The New Strategy for the Therapy of IRI--Cholinergic Anti-inflammatory Pathway

In the ischemic myocardium, reperfusion is necessary for the salvage of cells and cardiac function. However, reperfusion itself causes ＂reperfusion injury＂, leading to the damage of myocardial cells. In this process, it provokes an intense inflammatory response that initially exacerbates tissue injury. It is recently found that the efferent vague nerve inhibits pro--inflammatory cytokine release and protects against IRI and termed this vagal function ＂the cholinergic anti--inflammatory pathway＂. It provides a new strategy for the therapy of IRI.