| Abstract: | The experiments on mice (under the condition of agonistic interactions) have shown increases and decreases in certain forms of species-specific behavior (aggression, defense, sociability) when synthetic peptides and psychotropic drugs were administered. MIF-1, TRH, and LH-RH (acute injections) enhance aggression in isolated mice while somatostatin reduces it. MIF–1 antagonizes the antiaggressive effects of haloperidol, muscimol, and morphine. ACTH 1–24 counteracts the action of diaze-pam on attacks and threats. Somatostatin reduces both aggression and sociability and that effect may be potentiated by diazepam. Neo-endorphin injected together with diazepam reduces aggression and enhances sociability. A combination of synthetic neuropeptides and well known psychotropic drugs (neuroleptics, tranquil-izers, and others) may be more effective for the control of aggression and sociability than the psychotropic drugs employed alone. |
