PTEN、p53和BAG-1在三阴乳腺癌中的表达及意义

为了研究PTEN、p53和BAG-1在三阴乳腺癌中的表达情况及临床病理意义,并讨论三者之间的关系.采用免疫组织化学SP法检测89例三阴乳腺癌中PTEN、p53、BAG-1的表达,其阳性表达率分别为44.9％、47.2％、73.0％,三者的表达均与患者的病理组织学分级、淋巴结转移情况有关（P＜0.05）.PTEN的表达与p53、BAG-1表达呈负相关;BAG-1与p53的表达呈正相关,提示三者在三阴乳腺癌中的表达存在一定关联性,临床上联合检测三者可能为TNBC预后评估、患者的个体化治疗提供一定的参考.

Expression and Pathological Significance of PTEN,p53 and BAG-1 in Triple-negative Breast Carcinoma

To investigate the expressions of PTEN,p53 and BAG-1 protein in a series of triple negative breast cancers and to relate these expression to clinicopathologic features,and then to discuss the association between PTEN loss,p53 mutations and BAG-1 expression.A total of 89 formalin fixed and paraffin processed triple negative breast cancer cases which are from the First Affiliated Hospital of Liaoning Medical University were tested for PTEN,p53 and BAG-1 by immunohistochemistry.The resulting slides were scored for proportion and intensity of staining.Loss of tumor nuclear and cytoplasmic staining for PTEN occurred in 44.9％ of cases; The levels of p53,BAG-1 expression were seen in 47.2％,73.0％ of cases,The expression of PTEN,p53 and BAG-1 were significantly associated with histological grade,lymphnode metastasis.Our clinical study supports the preclinical finding of the interaction between PTEN,p53 and BAG-1.The combined detection of these three markers could indicate early pathological diagnosis and prognosis of breast carcinoma.But further experiments to explore the prognostic and therapeutic role of PTEN,p53 and BAG-1 in TNBC are warranted.