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脂肪干细胞复合脂肪颗粒促血管化的实验研究
引用本文:刘亚南,范崇盛. 脂肪干细胞复合脂肪颗粒促血管化的实验研究[J]. 医学与哲学(人文社会医学版), 2014, 0(9): 78-80
作者姓名:刘亚南  范崇盛
作者单位:郑州大学附属洛阳市中心医院耳鼻咽喉头颈外科,河南洛阳471000
摘    要:本研究探讨脂肪干细胞复合脂肪颗粒对裸鼠皮下血管化的影响。将12只裸鼠身上标记三个点,将三组试剂分别注射,分析结果如下:肉眼观察:取材时,裸鼠背部注射部皮下有一团状组织块,脂肪组织形状不规则,大小不一。微血管密度:A组明显高于B组、C组,且差异有统计学意义(P〈0.01);B组明显高于c组,且差异有统计学意义(P〈0.01)。存活率比较:A组明显高于B组、C组,且差异有统计学意义(P〈0.01);B组明显高于C组,且差异有统计学意义(P〈0.01)。脂肪颗粒作为生物支架可加速脂肪干细胞的促血管化作用,从而促进移植物的存活与生长。

关 键 词:脂肪干细胞  脂肪颗粒  血管化  生物支架

The Experimental Study of Promoting Neovascularization from Adipose Tissues Derived Stem Cells Combinding with Fat Particles
LIUYa-nan,FAN Chong-sheng. The Experimental Study of Promoting Neovascularization from Adipose Tissues Derived Stem Cells Combinding with Fat Particles[J]. Medicine & Philosophy:Humanistic & Social Medicine Edition, 2014, 0(9): 78-80
Authors:LIUYa-nan  FAN Chong-sheng
Affiliation:. Luoyang Center Hospital Affiliated to Zhengzhou University Otolaryngology Head and Neck Surgery, Luoyang 471000, China
Abstract:This paper disscussed the effect of promoting neovascularization from adipose tissues derived stem cells combining with fat particles. The experimental animals were selected from the same 12 nude, each nude muse was marked with 3 points and injected into the subcutaneous stratum of the 12 nude mice. Results as the follows: General observation,When drawn, we can see a group of tissue blocks in injected subcutaneously of nude mice, the sizes and shapes of adipose tissue were irregular. Microvessel density, group A was higher than group B and group C, and had significant statistically differences (P〈 0.01), group B was higher than group C, and had significant statistically differences (P〈 0. 01). Comparison of survival (%) , Group A was higher than group B and group C, and had significant statistically differences (P〈0.01), group B was higher than group C, and had significant statistically differences (P〈0. 01). As a cellular scaffold, fat particles can accelerate the vascularization of ADSCs and promote thesurvial and growth of transplanted ADSCs.
Keywords:adipose tissues derived stem cells   fat particles   neovascularization   cellular scaffold
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