| 神经嵌合体研究的伦理学刍议 |
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| 引用本文： | 王赵琛. 神经嵌合体研究的伦理学刍议[J]. 医学与哲学, 2022, 43(10): 1-6. doi: 10.12014/j.issn.1002-0772.2022.10.01 |
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| 作者姓名： | 王赵琛 |
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| 作者单位： | 浙江大学医学院公共卫生学院 浙江杭州 310058 |
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| 基金项目： | 2019年中国工程院咨询研究项目(2019-XZ-53)；2021年国家社会科学基金青年项目(21CZX053) |
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| 摘 要： | 神经嵌合体研究具有潜在重要的科研与社会价值，也引起了诸多伦理关注。聚焦于将人类神经组织、细胞或基因在非人动物中表达所引发的伦理问题：通过比较国际干细胞研究学会新旧指南关于嵌合体的定义，指出不同胚起源、“基因上不同”起源的嵌合体界定存在的问题，以及这些界定对伦理讨论的启示；结合科研进展探讨了受试动物福祉、道德地位变化等问题，以试图厘清人们对这类研究的关键忧虑；并在科学必要性与规范合理性的视角下提出针对性的治理建议。
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| 关 键 词： | 嵌合体 神经 干细胞 生命伦理学 |
| 收稿时间： | 2021-12-27 |
| 修稿时间： | 2022-04-20 |
An Ethical Discussion of Neural Chimera Research |
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| WANG Zhao-chen. An Ethical Discussion of Neural Chimera Research[J]. Medicine & Philosophy, 2022, 43(10): 1-6. doi: 10.12014/j.issn.1002-0772.2022.10.01 |
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| Authors: | WANG Zhao-chen |
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| Affiliation: | School of Public Health, School of Medicine, Zhejiang University, Hangzhou 310058, China |
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| Abstract: | Neural chimera research is of a unique kind that implicates crucial scientific and social values, with which the ethical concerns follow. This paper focuses on ethical issues about expressing human neural tissue, cells, or genes in nonhuman animals. By comparing the definition of chimera in the former and latest guideline of International Society for Stem Cell Research, this paper shows how the non-embryonic origins and genetically distinct concept of chimera would be problematic and its implication to ethical investigation. To articulate what really bothers us in the ethical sense, animal welfare and the moral status of nonhuman subjects have been discussed with the latest research. Some suggestions are put forward from the perspective of scientific necessity and normative rationality. |
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| Keywords: | chimera neuro stem cell bioethics |
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