Further analysis of encoding in patients with Huntington's disease |
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| Authors: | William W Beatty Nelson Butters |
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| Institution: | 1. Division of Functional and Restorative Neurosurgery, Centre for Integrative Neuroscience, Eberhard Karls University Tuebingen, Germany;2. Department of Neurology and Stroke, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Germany;3. MEG Center, Eberhard Karls University Tuebingen, Germany;1. Laboratory for Brain Recovery and Function, Dalhousie University, Halifax, Nova Scotia, Canada;2. School of Physiotherapy, Dalhousie University, Halifax, Nova Scotia, Canada;3. Department of Psychology and Neuroscience, Dalhousie University, Halifax Nova Scotia, Canada;4. Biomedical Translational Imaging Centre (BIOTIC), IWK Health Sciences Centre, Halifax, Nova Scotia, Canada;1. Coma Science Group, GIGA-Consciousness, University of Liège and University Hospital of Liège, Liège, Belgium;2. Centre du Cerveau, University Hospital of Liège, Liège, Belgium;1. Division of Translational Neurosurgery & Division of Functional and Restorative Neurosurgery, Department of Neurosurgery, and Centre for Integrative Neuroscience, University of Tuebingen, Germany;2. Department of Neurology and Stroke, and Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany |
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| Abstract: | Arguments favoring the view that derangement of normal encoding processes contributes to the memory defects of patients with Huntington's disease (HD) are supported by the finding that HD patients do not learn highly imageable words more rapidly than they learn words that are difficult to image. But other data indicating that HD patients can use verbal mediators as mnemonic aids for picture recognition question the existence of important and general encoding deficits in HD. In the first of two experiments the influence of imagery on the acquisition and recall of 14-word lists was studied using a free-recall paradigm. Both HD patients and controls learned highly imageable words more quickly and retained them better than low imagery words over a 30-min delay. The impact of imagery on learning was apparent by the first trial. In the second experiment, a modified Brown-Peterson distractor paradigm was used to assess release from proactive interference (PI). It was found that both HD patients and controls exhibited comparable release from PI following a shift in taxonomic categories. The results of both experiments question the importance of encoding deficits in the memorial dysfunctions associated with HD. |
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