Arousal-reducing effects of chronic stimulant use

A variety of studies withhabitual users of nicotine, caffeine, cocaine, and amphetamines have shown that administration of these stimulants has the paradoxical effect of lowering arousal states. Research on transmarginal inhibition shows that when subjects are presented with a succession of stimuli monotonically increasing in intensity, GSR and related arousal responses increase first and then begin to decline beyond a certain point of stimulus intensity. That is, following repeated exposure to intense stimuli, continued more intense stimulation has the effect of lowering arousal. Since stimulants subjectively heighten stimulus intensity, the transmarginal inhibition data provide a basis for explaining opposing effects of stimulants on arousal, depending on dose and frequency of use. It was hypothesized that when dose levels are low and usage is infrequent, arousal increases with stimulant intake. In contrast, when dose levels are high and frequent, arousal shows decrements with new intakes of stimulant. A new questionnaire measure of characteristic arousal was developed and correlated with subjects' reports of habitual levels of stimulant and sedative intake. Weekly total stimulant use correlated significantly and negatively with characteristic arousal level, providing support for the hypothesis. This lowered arousal of frequent stimulant users was not a confound of, or due to, concomitant frequent sedative use, since total stimulant and sedative use levels were uncorrelated.The author would like to thank Janice Schafrik for running the subjects in this study.