Prenatal maternal depression predicts neural maturation and negative emotion in infants |
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| Institution: | 1. Division of Biokinesiology and Physical Therapy, Herman Ostrow School of Dentistry, University of Southern California, USA,;2. Division of Behavioral Pediatrics, Department of Pediatrics, Keck School of Medicine, University of Southern California, USA,;3. Department of Innovation and Product Design, University Carlos III of Madrid, Spain,;4. Department of Computer Science, Viterbi School of Engineering, University of Southern California, USA,;5. Developmental Neuroscience and Neurogenetics Program, The Saban Research Institute, Children''s Hospital Los Angeles, USA;1. UiT The Arctic University of Norway, Norway;2. National Institute for Medical Research (NIMR), Tanzania;1. Regional Centre for Child and Youth Mental Health and Child Welfare, NORCE Norwegian Research Centre, Bergen, Norway;2. Innlandet Hospital Trust, Department of Research, Lillehammer, Norway;3. Department of Pediatrics, Child Health Research Project, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal;4. Department of Psychosocial Science, Faculty of Psychology, University of Bergen, Norway;5. Center for Intervention Science in Maternal and Child Health, Centre for International Health, University of Bergen, Bergen, Norway;6. Department of Community Medicine, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal;1. Faculty of Human Sciences, Osnabrück University, Germany;2. The Hebrew University Jerusalem, Israel;3. Instituto de Investigaciones Psicológicas, Universidad de Costa Rica, San José, Costa Rica;1. Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA;2. Department of Psychology, Xavier University (Emerita), USA;3. Washington - Baltimore Center for Psychoanalysis, USA;4. Department of Psychology, Pace University, New York, NY, USA;5. Department of Psychology, Hebrew University, Jerusalem, Israel;6. The Nathan Kline Institute, Orangeburg, NY, USA;1. American University, 4400 Massachusetts Ave NW, Washington, DC 20016, United States;2. Florida International University, 11200 SW 8th St. Miami, FL 33199, United States |
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| Abstract: | Despite widespread acceptance that prenatal symptoms of depression in mothers are detrimental to infants’ long-term emotional and cognitive development, little is known about the mechanisms that may integrate outcomes across these domains. Rooted in the integrative perspective that emotional development is grounded in developing cognitive processes, we hypothesized that prenatal symptoms of depression in mothers would be associated with delays in neural maturation that support sociocognitive function in infants, leading to more problematic behaviors. We used a prospective longitudinal study of mothers (N = 92) and their infants to test whether self-reported symptoms of depression in mothers during the second and third trimesters were associated with neural development and infant outcomes at 4 months of age. While controlling for postpartum symptoms of depression, more prenatal symptoms of depression in mothers predicted less neural maturation in the parietal region of 4-month-old infants. Less neural maturation, in turn, was associated with greater infant negativity, suggesting neural maturation as a putative mechanism linking maternal symptoms of depression with infant outcomes. Differences in neural regions and developmental timing are also discussed. |
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| Keywords: | Prenatal depression Alpha power Delta power Alpha-delta ratio Cognition-emotion interplay |
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