Preterm infant body composition,working memory,and temperament |
| |
| Institution: | 1. Division of Neonatology, University of Minnesota, Minneapolis, MN, USA;2. Center for Neurobehavioral Development, University of Minnesota, Minneapolis, MN, USA;3. HealthPartners Institute, Minneapolis, MN, USA;1. Studies and Research Department of the Italian Society of Relationship in Psychoanalysis, Italy;2. Unità Operativa Semplice Dipartimentale di Psicologia Clinica - Dipartimento Salute Mentale - ASST Brianza, Italy;3. Department of Psychology, Catholic University of the Sacred Heart, Milan, Italy;4. Department of Human and Social Sciences, University of Bergamo, Italy;5. 0–3 Center for the At-Risk Infant, Scientific Institute IRCCS Eugenio Medea, Bosisio Parini, Lecco, Italy;1. Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA;2. Department of Psychology, Xavier University (Emerita), USA;3. Washington - Baltimore Center for Psychoanalysis, USA;4. Department of Psychology, Pace University, New York, NY, USA;5. Department of Psychology, Hebrew University, Jerusalem, Israel;6. The Nathan Kline Institute, Orangeburg, NY, USA;1. Department of Psychology, University of Virginia, Charlottesville, VA, USA;2. Department of Pediatrics, Division of Developmental Medicine, Boston Children’s Hospital, Boston, MA, USA;3. Department of Pediatrics, Harvard Medical School, Boston, MA, USA;1. Ben-Gurion University of the Negev, Israel;2. Department of Obstetrics and Gynecology, Soroka University Medical Center, Israel;1. Department of Social and Educational Sciences of the Mediterranean Area, University for Foreigners of Reggio Calabria, Italy;2. Department of Psychology and Cognitive Science, University of Trento, Italy |
| |
| Abstract: | Altered body composition in preterm infants is associated with risks to cognitive development, but the effect specific to prefrontal cortex (PFC) development is unknown. We were interested in the impact of fat mass (FM) and fat free mass (FFM) gains out to 4 months corrected gestational age (CGA) on PFC development, as indexed by working memory and temperament. This is a prospective observational pilot study recruiting 100 preterm (<33 weeks gestation), appropriate for gestational age, and very low birth weight infants, of which 49 infants met inclusion criteria. Body composition was measured using air displacement plethysmography at hospital discharge and 4 months CGA. Questionnaire based temperament assessments were completed at 12 and 24 months CGA and a working memory assessment was completed at 24 months CGA. Associations between developmental tests and body composition obtained at term and 4 months were analyzed. Increased FM at discharge was associated with increased fear and decreased soothability at 12 months. Increased FM at 4 months was associated with increased activity level, increased distress from limitations at 12 months and decreased attentional shifting, decreased frustration, and decreased inhibitory control at 24 months. Increased FFM at 4 months was associated with increased activity level at 12 months and increased impulsivity and decreased low intensity pleasure at 24 months. In this exploratory pilot study, increased FM out to 4 months and increased FFM after discharge are associated with negative markers of infant temperament. Infant temperament may be sensitive to body composition status at least to 4 months CGA. |
| |
| Keywords: | Prefrontal cortex Neurodevelopment Infant temperament Body composition Preterm infant |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
