Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments |
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| Authors: | Goodrich-Hunsaker Naomi J Wong Ling M McLennan Yingratana Srivastava Siddharth Tassone Flora Harvey Danielle Rivera Susan M Simon Tony J |
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| Affiliation: | a NeuroTherapeutics Research Institute, University of California, Davis Medical Center, United States;b Neuroscience Graduate Group, University of California, Davis, United States;c M.I.N.D. Institute, University of California, Davis Medical Center, United States;d Department of Biochemistry and Molecular Medicine, University of California, Davis, United States;e Department of Public Health Sciences, University of California, Davis, United States;f Department of Psychology, University of California, Davis, United States;g Department of Psychiatry and Behavioral Sciences, University of California, Davis, United States |
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| Abstract: | The high frequency of the fragile X premutation in the general population and its emerging neurocognitive implications highlight the need to investigate the effects of the premutation on lifespan cognitive development. Until recently, cognitive function in fragile X premutation carriers (fXPCs) was presumed to be unaffected by the mutation. Here we show that young adult female fXPCs show subtle, yet significant, age- and FMR1 gene mutation-modulated cognitive impairments as tested by a quantitative magnitude comparison task. Our results begin to define the neurocognitive endophenotype associated with the premutation in adults, who are at risk for developing a neurodegenerative disorder associated with the fragile X premutation. Results from the present study may potentially be applied toward the design of early interventions wherein we might be able to target premutation carriers most at risk for degeneration for preventive treatment. |
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| Keywords: | Fragile X premutation carrier Adult Women Parietal lobe Magnitude Numerical Spatial |
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