Postextinction infusion of a mitogen-activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear |
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Authors: | Hugues Sandrine Deschaux Olivier Garcia René |
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Affiliation: | Neurobiologie Comportementale, JE Neurobiologie & Psychopathologie, Université de Nice-Sophia Antipolis, 06108 Nice, France. |
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Abstract: | We investigated whether postextinction training infusion of PD098059, a selective inhibitor of mitogen-activated protein kinase (MAPK) activation, into the medial prefrontal cortex, would impair retention of extinction learning in rats. We found that immediate, but not late (2 or 4 h), postextinction infusion of PD098059 provoked a full return of conditioned freezing. These results suggest that activation of prefrontal MAPK in early stages of postextinction training participates in processes that protect against spontaneous recovery of aversive responses. |
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