Development of clinical tests of vision: Initial data on two hyperacuity paradigms

Many basic psychophysical functions offer promise as clinical tests of vision. Here, we discuss problems that one encounters in the clinical setting, how one identifies a psychophysical test for potential clinical development, and an orderly approach to development of suitable test paradigms. Parameters are selected which are relatively insensitive to variables encountered in the field (clinic) in a normal population, but which are sensitive to changes in the response system being studied. Initial data on two hyperacuity tests are presented. These tests are adaptations of hyperacuity paradigms (Westheimer, 1979) to a clinical environment. This particular test set offers promise because it exhibits a unique threshold which is dependent upon neural data processing and is relatively independent of retinal image degradation.