Midline theta dissociates agentic extraversion and anhedonic depression |
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| Affiliation: | 1. Department of Clinical Psychology and Psychotherapy, Justus-Liebig Universität Gießen, Germany;2. Center for Depression, Anxiety, and Stress Research, McLean Hospital & Harvard Medical School, United States;3. Institute for Psychology, Hamburg University, Germany;1. Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania;2. Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois;1. Department of Psychology, Stony Brook University, Stony Brook, NY 11794, USA;2. Emotion and Development Branch, National Institute of Mental Health (NIMH), Bethesda, MD 20892, USA;3. Department of Psychiatry, Washington University in St. Louis, St. Louis, MO 63130, USA;4. Department of Psychology, Washington University in St. Louis, St. Louis, MO 63130, USA;5. Department of Radiology, Washington University in St. Louis, St. Louis, MO 63130, USA;6. Neuroscience Program, Washington University in St. Louis, St. Louis, MO 63130, USA;1. Center for Depression, Anxiety and Stress Research, McLean Hospital, Belmont, Massachusetts;2. Department of Psychiatry, Harvard Medical School, Boston, Massachusetts;3. Department of Psychology and Neuroscience, Duke University, Durham, North Carolina;4. Department of Psychological and Brain Sciences, Washington University, St. Louis, Missouri;5. Department of Psychiatry, Columbia University, New York, New York;6. Division of Clinical Developmental Neuroscience, Sackler Institute, New York, New York;1. Yale Child Study Center, Yale School of Medicine, 230 South Frontage Rd., New Haven, CT 06520, USA;2. Whiting School of Engineering, Johns Hopkins University, 3400 N Charles St., Baltimore, MD 21218, USA;3. Departments of Psychology and Neuroscience, Brigham Young University, Provo, UT 84602, USA;1. Stony Brook University, United States;2. Purdue University, United States |
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| Abstract: | The agency facet of extraversion is related to individual differences in reward anticipation and has been linked to the neurotransmitter dopamine. Dopamine has also been associated with components of anhedonia, which is one of the cardinal symptoms of depression and refers to lack of responsiveness to pleasurable stimuli. This raises the question whether low agency is associated with anhedonia symptoms in depression and if agency and anhedonia are characterized by similar neurobiological mechanisms. To address this hypothesis, we tested whether questionnaire measures of agency and anhedonia are correlated within depressed (n = 20) and non-depressed (n = 22) participants. Further, we investigated whether dopamine-related signatures in the EEG recorded during a gambling task (feedback-evoked theta activity, and frontal versus posterior theta activity) similarly relate to agency and anhedonia. Results indicated that anhedonia was significantly elevated in the depression group, and negatively correlated with agency. However, while theta activity evoked by negative vs. positive feedback was sensitive to anhedonia and depression status but unrelated to agency, frontal versus parietal theta activity predicted agency, but was unrelated to anhedonia and depression. Together, this double dissociation suggests that in spite of considerable phenotypical overlap, anhedonia and agency may be linked to partially distinct neurobiological markers. |
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| Keywords: | Feedback EEG Extraversion BAS Depression Theta |
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