A genetic variant (COMT) coding dopaminergic activity predicts personality traits in healthy elderly |
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| Affiliation: | 1. Department of Psychology, Washington University in St. Louis, One Brookings Drive, MO 63130, USA;2. Institute of Psychology, Eötvös Loránd University, Budapest, Izabella u. 46., H-1064, Hungary;3. Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, MO 63110, USA;1. Department of Pancreatic Surgery, Institute of Pancreatic Disease, Shanghai Huashan Hospital, Fudan University, Shanghai, China;2. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China;3. Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China;4. Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL, United States;1. Department of Psychiatry, Weill Cornell Medical College of Cornell University, New York, New York.;2. Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York.;3. Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, New York.;1. University Hospital Marqués de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain;2. CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain;3. IDIVAL, Instituto de Investigación Marqués de Valdecilla, Santander, Spain;4. Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain |
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| Abstract: | Association studies between the NEO five factor personality inventory and COMT rs4680 have focused on young adults and the results have been inconsistent. However, personality and cortical changes with age may put older adults in a more sensitive range for detecting a relationship. The present study examined associations of COMT rs4680 and personality in older adults.Genetic association analyses were carried out between the NEO and the targeted COMT rs4680 in a large, well-characterized sample of healthy, cognitively normal older adults (N = 616, mean age = 69.26 years).Three significant associations were found: participants with GG genotype showed lower mean scores on Neuroticism (p = 0.039) and higher scores on Agreeableness (p = 0.020) and Conscientiousness (p = 0.006) than participants with AA or AG genotypes.These results suggest that older adults with higher COMT enzymatic activity (GG), therefore lower dopamine level, have lower Neuroticism scores, and higher Agreeableness and Conscientiousness scores. This is consistent with a recent model of phasic and tonic dopamine release suggesting that even though GG genotype is associated with lower tonic dopamine release, the phasic release of dopamine might be optimal for a more adaptive personality profile. |
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| Keywords: | Genetic association Personality Dopamine COMT rs4680 polymorphism Older adults |
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