| Abstract: | The fear-potentiating effects of fluprazine hydrochloride were explored in a series of five experiments. The drug was found to strongly inhibit entry into a novel open field, exploration of a complex maze, or approach to a novel object placed in the animal's home cage. Time sampling techniques were used to assess drug effects on frequencies of immobility, activity, and grooming and rearing responses prior to and for 70 min after footshock. There were no group differences during the 10 min immediately following shock but the groups diverged steadily in immobility, activity, and grooming for the remainder of the observations. Post-shock activity and grooming responses increased steadily towards baseline values among control mice but remained at low levels or declined among drug-treated mice. Immobility responses declined steadily among control mice but increased substantially among the fluprazine-treated mice throughout post-shock observations. Pairs of male mice treated with fluprazine were also found to maintain greater intermouse distances in a novel linear runway than pairs of undrugged adult males, juvenile males, or male-female pairs. It is suggested that fluprazine hydrochloride both potentiates fear and alters its time course in addition to interfering in some way with normal olfactory processes. |
