BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure |
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Authors: | Francesco Angelucci Valerio Ricci Francesca Gelfo Giovanni Martinotti Marcella Brunetti Gianna Sepede Maria Signorelli Eugenio Aguglia Mauro Pettorruso Federica Vellante Massimo Di Giannantonio Carlo Caltagirone |
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Institution: | 1. IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, 00179 Rome, Italy;2. Department of Neuroscience and Imaging, University “G.d’Annunzio”, Chieti, Italy;3. Department of Psychiatry, University of Catania, Italy;4. Department of Neuroscience, Catholic University of Rome, Italy |
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Abstract: | Post-traumatic stress disorder (PTSD) is a syndrome resulting from exposure to a severe traumatic event that poses threatened death or injury and produces intense fear and helplessness. The neural structures implicated in PTSD development belong to the limbic system, an important region for emotional processing. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that serves as survival factor for selected populations of central nervous system (CNS) neurons and plays a role in the limbic system by regulating synaptic plasticity, memory processes and behavior. Impaired BDNF production in the brain can lead to a variety of CNS dysfunctions including symptoms associated with PTSD. However, so far fewer studies have investigated this neurotrophin in patients with PTSD. Furthermore, given the multiple role of BDNF in various CNS disorders, it cannot be excluded that traumatic events per se may influence neurotrophin levels, without a direct association to the PTSD syndrome. |
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Keywords: | Post-traumatic stress disorder Trauma exposure BDNF ELISA |
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