Central action of substance P: possible role in reward |
| |
| Authors: | U St?ubli J P Huston |
| |
| Affiliation: | 1. Department of Physical Therapy, The Stanley Steyer School of Health Professions, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel;2. Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel;3. Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom;4. Faculty of Philosophy, University of Cambridge, Cambridge, United Kingdom;5. Cambridgeshire and Peterborough National Health Service Foundation Trust, Elizabeth House, Fulbourn, Cambridge, United Kingdom;6. Wellcome Trust Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom;1. Institution of Refrigeration and Cryogenics, Zhejiang University, Hangzhou, 310027, China;2. Department of Soils, Water and Agricultural Engineering, College of Agricultural & Marine Sciences, Sultan Qaboos University, Oman;3. School of Engineering, Durham University, Durham, DH1 3LE, UK;1. Center for Contextual Psychiatry, Department of Neuroscience, KU Leuven − Leuven University, Leuven, Belgium;2. Division of Nuclear Medicine and Molecular Imaging, Department of Imaging & Pathology, University Hospitals Leuven, Leuven, Belgium;3. Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, USA;4. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands;5. Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;6. Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany |
| |
| Abstract: | A series of studies had revealed a dualistic role of post-trial injections of substance P in affecting avoidance behavior depending on the site of the brain in which it is applied. Based on these data, the hypothesis was formulated that substance P has brain site-dependent rewarding and punishing properties, a possibility which was assessed in rats trained on a modified T-maze task. Injections of substance P into the medial forebrain bundle (100 ng) or medial septal nucleus (500 ng) served as a positive reinforcer for conditioned place preference learning in the T maze. Injections into the amygdala (50 ng) or substantia nigra (100 ng) did not have such reinforcing properties. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
