| 综合分析基础上重新认识再生障碍性贫血——从“综合征”到“自身免疫性疾病” |
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| 引用本文： | 王一浩,张金钟,邵宗鸿.综合分析基础上重新认识再生障碍性贫血——从“综合征”到“自身免疫性疾病”[J].医学与哲学,2008,29(3):31-33. |
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| 作者姓名： | 王一浩 张金钟 邵宗鸿 |
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| 作者单位： | [1]天津医科大学总医院血液肿瘤科,天津300052 [2]天津医科大学,天津300070 |
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| 摘 要： | 此前认为再生障碍性贫血是以多种机制导致骨髓造血功能衰竭以外周血细胞减少为特征的一组异质性疾病群，研究发现此类患者体内，CD3＋CD8＋T淋巴细胞数目增加、CD4＋／CD8＋T淋巴细胞比值降低、T细胞功能亢进、Th1型细胞因子分泌增多。综合分析认为再生障碍性贫血是以Th1细胞异常活化导致自身反应性T淋巴细胞功能亢进导致造血干祖细胞损伤的一种自身免疫性疾病。
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| 关 键 词： | 综合研究 再生障碍性贫血 自身免疫性疾病 |
Re-recognition of Aplastic Anemia Based on Synthetic Analysis |
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| Institution: | WANG Yi-hao, ZHANG Jin-zhong, SHAO Zong-hong. (Department of hematology and oncology of General Hospital of Tianjin Medical University , Tianjin 300052 ,China ) |
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| Abstract: | Aplastic anemia （AA） was characteristic of haemocytopenia caused by many mechanisms before, Studies had shown that the number of CD3 ＋ CD8 ＋ T lymphocytes was increased, the ratio of CD4 ＋/CD8 ＋ T lymphocytes was decreased, T lymphocytes over functioned and cytokines of Th1 cells was overfull secreted. Based on the synthetic analysis, AA was an autoimmune disease which pathogenesis was that hematopoietic stem/progenitor cells were damaged by overfunction of autoimmune T lymphocytes induced by Thl cells abnormally activated. |
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| Keywords: | synthetic analysis aplastic anemia autoimmune disease |
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