| 丙戊酸增强人罗同巢癌耐药细胞株COC1／DDP对顺铂敏感性的研究 |
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| 引用本文： | 王凤琴,陈学娟,张向宁.丙戊酸增强人罗同巢癌耐药细胞株COC1／DDP对顺铂敏感性的研究[J].医学与哲学,2010(4):48-50. |
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| 作者姓名： | 王凤琴 陈学娟 张向宁 |
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| 作者单位： | 山东大学齐鲁医院妇产科,山东济南250012 |
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| 摘 要： | 探讨丙戊酸是否增强COC1/DDP对顺铂的敏感性并初步探讨其机制。采用WST-1、流式细胞术、免疫细胞化学法。结果丙戊酸与顺铂联合对细胞生长抑制和凋亡诱导明显强于顺铂组；NF-κB P65的表达量顺铂组高于对照组，联合组明显低于顺铂组。因此，丙戊酸增强COC1/DDP对顺铂的敏感性，且与NF-κB有关。
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| 关 键 词： | 卵巢肿瘤 丙戊酸 NF-κB 凋亡 |
VPA increase the Sensitivity of Human Ovarian Cancer Cell Line COC1/DDP to Cisplatin in Vitro |
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| WANG Feng-qin,CHEN Xue-juan,ZHANG Xiang-ning.VPA increase the Sensitivity of Human Ovarian Cancer Cell Line COC1/DDP to Cisplatin in Vitro[J].Medicine & Philosophy:Humanistic & Social Medicine Edition,2010(4):48-50. |
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| Authors: | WANG Feng-qin CHEN Xue-juan ZHANG Xiang-ning |
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| Institution: | . (Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji＇nan 250014, China) |
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| Abstract: | To investigate the inhibitory effects of valproic acid on enhancing chemosensitivity of drug resistant ovarian cancer cell line to cisplatin and expression of NF-κB P65 .We used the WST-1 assay、the Flow Cytometry and the Immunocytochemical meth-od.The results were that the effects of VPA＋DDP on cell antiproliferation and apoptosiswere more significant compared with those treated with DDP only.The expression of NF-κB P65 increased with DDP used only and decreased obviously with VPA＋DDP. Therefore VPA could increase the sensitivity of COC1/DDP to cisplat-in,and the effect related with NF-κB . |
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| Keywords: | ovarian neoplasm valproic acid nuclear factor-κB apoptosis |
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