从指南看TIA概念的演变及临床意义

短暂性脑缺血发作(TIA)的概念从20世纪50年代提出至今已有50余年,随着临床研究的深入和神经影像学技术的进步,人们对TIA的认识发生了深刻的变化。美国心脏协会(AHA)、美国卒中协会(ASA)在2009年6月发表最新指南提出TIA是由脑、脊髓或视网膜局灶性缺血引起的短暂性神经功能障碍,且无急性脑梗死证据。本文对新指南进行了解读,并对TIA概念的演变进行了简单回顾,同时探讨这种演变的临床意义。

The Evolution and the Value of the Definition of Transient Ischemic Attack from the New Guideline

There were 50 years passed since the definition of transient ischemic attack （TIA） was first established in 1950s. The traditional concepts of TIA have considerably changed with the improvement of clinical studies and the advance of neu- roimaging techniques. In June, 2009, American Heart Association, American Stroke Association published a new guideline which considers that TIA is a transient episode of neurological dysfunction caused by brain, spinal cord or focal retinal is- chemia,without the evidence of acute infarction. This article will review the evolution of TIA＇s concept and take some dis- cussion on the clinical significance of new definition.