重型颅脑损伤围术期亚低温治疗路径——循证医学指导下的治疗抉择

早期动物实验研究表明亚低温能减轻脑损伤后的继发性损害,促进神经功能恢复,然而对其临床疗效不同研究结果不完全一致。本文应用循证医学思想,检索和评价国内外文献,为重型颅脑损伤患者制定了围术期亚低温实施方案。随访结果表明,亚低温可改善患者预后。

Evidence--based Perioperative Mild Hypothermia Treatment for a Patient after Severe Traumatic Brain Injury

Severe traumatic brain injury is associated with high mortality and possibility to cause long-lasting disability. The early experimental studies showed that mild hypothermia treatment could limit secondary brain injury and promote the recovery. However, clinical studies differ in the efficacy of induced hypothermia. Search was conducted on certain electronic databases. The result shows that treatment of traumatic brain injury with moderate hypothermia could hasten neurologic recovery and improve the outcome.