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White-matter microstructure and language lateralization in left-handers: A whole-brain MRI analysis |
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| Authors: | Gabor Perlaki Reka Horvath Gergely Orsi Mihaly Aradi Tibor Auer Eszter Varga Gyongyi Kantor Anna Altbäcker Flora John Tamas Doczi Samuel Komoly Norbert Kovacs Attila Schwarcz Jozsef Janszky |
| Institution: | 1. Department of Neurology, University of Pecs, Ret u. 2, 7623 Pecs, Hungary;2. Pecs Diagnostic Centre, Ret u. 2, 7623 Pecs, Hungary;3. MTA-PTE Clinical Neuroscience MR Research Group, Ret u. 2, 7623 Pecs, Hungary;4. Biomedizinische NMR Forschungs GmbH am Max-Planck Institut für Biophysikalische Chemie, Am Fassberg 11, 37070 Göttingen, Germany;5. Central Department of Radiology, Hospital Markusovszky, Markusovszky u. 5, 9700 Szombathely, Hungary;6. Department of Psychiatry and Psychotherapy, University of Pecs, Ret u. 2, 7623 Pecs, Hungary;g Department of General Linguistics, University of Pecs, Ifjusag u. 6, 7624 Pecs, Hungary;h Department of Neurosurgery, University of Pecs, Ret u. 2, 7623 Pecs, Hungary |
| Abstract: | Most people are left-hemisphere dominant for language. However the neuroanatomy of language lateralization is not fully understood. By combining functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), we studied whether language lateralization is associated with cerebral white-matter (WM) microstructure. Sixteen healthy, left-handed women aged 20–25 were included in the study. Left-handers were targeted in order to increase the chances of involving subjects with atypical language lateralization. Language lateralization was determined by fMRI using a verbal fluency paradigm. Tract-based spatial statistics analysis of DTI data was applied to test for WM microstructural correlates of language lateralization across the whole brain. Fractional anisotropy and mean diffusivity were used as indicators of WM microstructural organization. Right-hemispheric language dominance was associated with reduced microstructural integrity of the left superior longitudinal fasciculus and left-sided parietal lobe WM. In left-handed women, reduced integrity of the left-sided language related tracts may be closely linked to the development of right hemispheric language dominance. Our results may offer new insights into language lateralization and structure–function relationships in human language system. |
| Keywords: | Diffusion tensor imaging Functional magnetic resonance imaging Atypical speech laterality Left-handers Superior longitudinal fasciculus Superior parietal lobe |
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