The free and cued selective reminding test for predicting progression to Alzheimer's disease in patients with mild cognitive impairment: A prospective longitudinal study |
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| Authors: | Raquel Lemos João Marôco Mário R. Simões Beatriz Santiago José Tomás Isabel Santana |
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| Affiliation: | 1. Faculty of Psychology and Educational Sciences, University of Coimbra, Portugal;2. Visual Neuroscience Laboratory, Institute of Biomedical Research in Light and Image, Faculty of Medicine, University of Coimbra, Portugal;3. Psychology and Health Research Unit (UIPES), Department of Psychological Sciences, ISPA – Instituto Universitário, Lisboa, Portugal;4. Neurology Department of the Coimbra Hospital and University Center, Portugal;5. Faculty of Medicine, University of Coimbra, Portugal |
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| Abstract: | Amnestic mild cognitive impairment (aMCI) patients carry a greater risk of conversion to Alzheimer's disease (AD). Therefore, the International Working Group (IWG) on AD aims to consider some cases of aMCI as symptomatic prodromal AD. The core diagnostic marker of AD is a significant and progressive memory deficit, and the Free and Cued Selective Reminding Test (FCSRT) was recommended by the IWG to test memory in cases of possible prodromal AD. This study aims to investigate whether the performance on the FCSRT would enhance the ability to predict conversion to AD in an aMCI group. A longitudinal study was conducted on 88 aMCI patients, and neuropsychological tests were analysed on the relative risk of conversion to AD. During follow‐up (23.82 months), 33% of the aMCI population converted to AD. An impaired FCSRT TR was significantly associated with the risk of conversion to dementia, with a mean time to conversion of 25 months. The FCSRT demonstrates utility for detecting AD at its prodromal stage, thus supporting its use as a valid clinical marker. |
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| Keywords: | free and cued selective reminding test mild cognitive impairment Alzheimer's disease longitudinal memory |
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