Clinical and pathol-anatomic findings in corpus callosum deficiency, enlarged cavum septi pellucidi, and septal defect]

A comparison is made of the pathological changes of the median line structures such as corpus deficiency, enlarged cavum septi pellucidi (Csp.) and septal defects in 10,457 pneumo-encephalography (PEG) examinations of neurological and psychiatric patients, and in 11,016 general autopsy cases. Clinical peculiarities in corpus deficiency and other development anomalies of the median line structures are discussed along with case reports. A predominance of the male sex in cases of enlarged Csp. together with frequent combinations with neurological and psychiatric illness were noticeable, particularly oligophrenia, behavioral disorders, epilepsy and cerebral tumours. Thus, certain inferiority of the dysrhaphic mutation of the central organ can be assumed.