The effects of scopolamine upon verbal memory: evidence for an attentional hypothesis |
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| Authors: | M P Dunne L R Hartley |
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| Affiliation: | 1. School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China;2. College of Chinese Medicines, Guangzhou University of Chinese Medicine, Guangzhou, PR China;1. University of South Carolina School of Medicine, Department of Pharmacology, Physiology, & Neuroscience, Columbia, SC, United States;2. University of South Carolina, Department of Psychology, Columbia, SC, United States;3. Wm. Jennings Bryant Dorn VA Medical Center, Columbia, SC, United States;1. Department of Biochemistry, Faculty of Life Sciences, A.M. University, Aligarh, U.P. 202002, India;2. Department of Chemistry, Faculty of Science, A.M. University, Aligarh, U.P. 202002, India;3. Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India;1. Section of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, South Kensington, London SW7 2AZ, UK;2. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Huddinge, Sweden;3. Translational Safety, AstraZeneca, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK;1. Maastricht University, Department of Psychiatry and Psychology, Maastricht, The Netherlands;2. Academic Medical Center, Department of Nuclear Medicine, Amsterdam, The Netherlands;3. GGZ Centraal, Center for Mental Health Care Innova, Amersfoort, The Netherlands;4. Neuropsychology and Applied Cognitive Neuroscience Laboratory; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;5. Department of Psychology, University of Chinese Academy of Sciences, Beijing, China;1. Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain;2. Research Institute of Aging, University of Murcia, 30100 Murcia, Spain;3. Department of Neurology, Santa Lucía University General Hospital, 30202 Cartagena, Spain |
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| Abstract: | Immediate and delayed free recall and recognition of dichotically presented lists of nouns were assessed in a group of normal female volunteers following oral administration of either a placebo or 0.6 mg scopolamine hydrobromide. Results show that, while there was no drug effect upon total (i.e., attended plus unattended) recall, there was a significant drug by attention interaction, in that recall for attended words was impaired while unattended recall was facilitated. There were no drug effects upon recognition performance. It was concluded that scopolamine acts to modulate selective attention rather than memory consolidation processes, and it is suggested that the cholinergic system may be centrally involved in the control of effortful or intentional processing in memory. |
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