K-ras基因与结直肠腺癌关系研究进展

肿瘤的发生涉及癌基因的激活及抑癌基因的失活,K-ras基因是与肿瘤形成关系较为密切的一种癌基因,其功能异常能够影响细胞的生长、增殖、分化和凋亡等。研究已发现K-ras基因的突变激活是结直肠癌变过程中的重要事件之一。本文拟对K-ras基因的生物学特性、对细胞信号转导的影响及在结直肠腺癌形成与治疗中的作用作一综述。

Research Advancement on Relationship Between K-ras Gene and Colorectal Adenocarcinowa

Carcinogenesis is a multistep process involving many oncogene activations and tumour suppressor gene inactivation. K--ras gene is one of the most common mutated oncogenes relating to carcinogenesis, its dysfunction can affect cell survival, proliferation, differentiation, and apoptosis, et al. Study have showed that K--ras gene played an important role in tumor development and progression of colorectat carcinoma. In this article,we will summarize the biological properties of K--ras gene, its influence on cell signaling, its role in colorectal tumor genesis and therapy.