Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine |
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| Authors: | Scott-McKean Jonah J Costa Alberto C S |
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| Institution: | Neuroscience Training Program, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045, USA. |
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| Abstract: | The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 μM NMDA for 3 min and 50 μM DHPG for 5 min, respectively. We found that Ts65Dn mice display exaggerated NMDA-induced, but not mGluR-induced, LTD in the CA1 region of the hippocampus compared with euploid control animals. In addition, this abnormal level of LTD can be pharmacologically rescued by the NMDA receptor antagonist memantine. |
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