条件性恐惧记忆提取消退干预范式

提取消退(retrieval-extinction, Ret+Ext)范式是基于记忆再巩固理论, 利用消退训练(extinction, Ext)能改变条件刺激(conditioned stimulus, CS)的恐惧效价特点, 把消退训练应用到再巩固时间窗内来改写(rewrite)恐惧记忆, 消除恐惧反应。提取消退范式是对传统暴露疗法和药物治疗的创新和拓展, 不仅为创伤性记忆的治疗提供一种非侵入性的技术, 而且也为改写人类记忆、积极心理学探索人类幸福感方面开辟了一种全新的理论视角。

A Retrieval-Extinction Paradigm to Treat Conditioned Fear Memory

Based on the reconsolidation theory of memory, the retrieval-extinction paradigm employ the extinction training within the reconsolidation window to rewrite fear memory of subjects and reduce their fear response by decreasing the valence of fear stimulus. The Ret+Ext paradigm is an innovation and development of traditional exposure therapies and drug treatment. It provides a new non-invasive model for trauma treatments and a new theoretical perspective for the rewriting human memory and the exploring human well-beings on the Positive Psychology.