樟柳碱所致学习和记忆障碍动物模型的探讨

本实验采用水迷津法、步下法和步入法,用樟柳碱制备学习和记忆障碍的动物模型。结果表明,樟柳碱(10毫克/公斤)可使小鼠引起学习障碍,其表现为通过水迷津全程的时间延长,而且小鼠进入盲路的错误次数明显增多。樟柳碱(10毫克/公斤)可使小鼠引起记忆障碍,在樟柳碱的影响下,小鼠步下平台或步入暗箱的潜伏期明显缩短,并使它们的错误次数增多。本实验结果进一步表明,测定小鼠的记忆障碍,步入法似乎比步下法更为敏感。

INVESTIGATION INTO ANIMAL MODELS OF LEARNING AND MEMORY DISORDER INDUCED BY ANISODINE

Using anisodine to prepare animal models of learning and memory disorder with water maze test, step clown test and step through test in mice was intro- duced in this paper. The results showed, anisodine (10 mg/kg)could significantly induce learning disorder in mice. Time through all pathways in the water maze was prolonged and errors in passing the blind alleys obviously increased. Anis- odine(10mg/kg)could significantly produce mempry dysfunction in mice: the latencies of the step down test and step through test were significantly shorten- ed, and errors of response in the step down test and step through test increased. The results futher indicated that the step through test is more sensitive than the step down test for testing memory dysfunction in mice.