5, 7-dihydroxytryptamine lesions: Effects on body weight,irritability, and muricide

Forty-four male rats were subjected to injections of 5,7dhydroxytryptamine (40 μg/4 μ1) in the ascending 5-hydroxytryptamine projection or control operations. The injections resulted in depletion of forebrain 5-hydroxytryptamine, weight loss, irritability, and muricide. No significant correlations were found between any of these effects. It is suggested that the neural systems mediating regulation of body weight and muricide are substantially distinct.